Salbutamol (hydrochloride)|cas 50293-90-8|DC Chemicals

Cas No.:	50293-90-8
Chemical Name:	Levalbuterol hydrochloride
Synonyms:	Levalbuterol hydrochloride;(R)-Albuterol Hydrochloride;(R)-ALBUTEROL HYDROCHLORIDE,OFF-WHITE SOLID;(R)-salbutamol hydrochloride Levosalbutamol hydrochloride;(R)-salbutamol hydrochloride;Levosalbutamol hydrochloride
SMILES:	Cl.OCC1=CC(=CC=C1O)[C@H](O)CNC(C)(C)C
Formula:	C₁₃H₂₁NO₃^.HCl
M.Wt:	275.77
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Salbutamol is an agonist of the β2-adrenergic receptor (β2-AR; Kd = 759 nM in a radioligand binding assay using CHO cells expressing the human receptor).It is selective for β2-ARs over β1- and β3-ARs (Kds = 46.8 and 21.9 μM, respectively). Salbutamol (25-50 μg/kg, i.v.) reduces acetylcholine-induced bronchospasm in anesthetized guinea pigs.It also reduces response of bronchial muscle to efferent vagal stimulation in anesthetized cats and dogs when administered at doses ranging from 1 to 2.5 and 10 to 20 μg/kg, respectively. Nebulized salbutamol reduces transpulmonary pressure in recurrent airway obstruction-affected horses (EC50 = 39.7 μg).Formulations containing salbutamol have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).

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