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SB-216

  Cat. No.:  DC49574   Featured
Chemical Structure
2756818-39-8
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More than 5000 active chemicals with high quality for research!
Field of application
SB-216 is a potent tubulin polymerization inhibitor. SB-216 shows strong antiproliferative potency in a panel of human cancer cell lines, including melanoma, lung cancer, and breast cancer.  SB-216 can be used for cancer research.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2756818-39-8
Chemical Name: SB-216
Synonyms: SB-216;Y5M;CHEMBL4855608;MS-24513;2756818-39-8;CS-0436217;HY-144898;SCHEMBL25415099;AKOS040758954;7-methoxy-4-(2-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3,4-dihydroquinoxalin-2(1H)-one;GLXC-26505
SMILES: O=C1NC2=CC(OC)=CC=C2N(C2N=C(C)N=C3CCCC=23)C1
Formula: C17H18N4O2
M.Wt: 310.35
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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DC71742 MY-875 MY-875 is a competitive microtubulin polymerization inhibitor with an IC50 value of 0.92 μM. MY-875 inhibits microtubulin polymerization by targeting colchicine binding sites and activates the Hippo pathway. MY-875 induces apoptosis and has anticancer activity.
DC49574 SB-216 SB-216 is a potent tubulin polymerization inhibitor. SB-216 shows strong antiproliferative potency in a panel of human cancer cell lines, including melanoma, lung cancer, and breast cancer.  SB-216 can be used for cancer research.
DC49572 (R)-AM-5308 AM-5308 is a potent and selective KIF18A inhibitor with demonstrated antitumor activity in cell-based and animal models. Its ability to disrupt mitosis and induce cancer cell death makes it a promising candidate for further development as a cancer therapeutic.
DC48439 Verubulin hydrochloride Verubulin hydrochloride(MPC 6827 hydrochloride) is a microtubule destabilizer and vascular disrupting agent that achieve high brain concentration relative to plasma in animals.
DC47191 Sovilnesib(AMG-650) Sovilnesib(AMG650) is a kinesin-like protein KIF18A inhibitor (WO2020132648). Sovilnesib can be used for the research of cancer.
DC42297 Vc-MMAD Vc-MMAD consists the ADCs linker (Val-Cit) and potent tubulin (MMAD). Vc-MMAD is a drug-linker conjugate for ADC.
DC40078 MAP4343 MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents.
DC5882 Fosbretabulin disodium Fosbretabulin disodium(CA 4DP; CA 4P) is a microtubule destabilizing drug, a type of vascular-targeting agent, a drug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis.
DC4198 Epothilone B Epothilone B is a Taxol-like microtubule-stabilizing agent with EC0.01 of 1.8 μM.
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