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Tebideutorexant

  Cat. No.:  DC71984  
Chemical Structure
1637681-55-0
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More than 5000 active chemicals with high quality for research!
Field of application
Tebideutorexant is a potent orexin receptor antagonist. Tebideutorexant can be used for insomnia research.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1637681-55-0
Chemical Name: Tebideutorexant
SMILES: O=C(C1=C(C2=NC=CC=N2)C(F)=CC=C1)N3[C@@H]4[C@@H](C[C@H](C3([2H])[2H])C4)OC5=CC=C(C=N5)C(F)(F)F
Formula: C23H16D2F4N4O2
M.Wt: 460.42
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC73482 CVN766 CVN766 (CVN 766) is a potent, exquisitely selective orexin 1 receptor (OX1R) antagonist with IC50 of 8 nM, 1000-fold selective over OX2R.
DC73480 (R)-YNT-3708 (R)-YNT-3708 is a potent, selective orexin 1 receptor (OX1R) agonist with EC50 of 7.48 nM and Emax 101%, 22-fold selectivity over OX2R (IC50=168 nM).
DC71983 Nivasorexant Nivasorexant is a potent orexin receptor antagonist.
DC28252 Seltorexant hydrochloride Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant hydrochloride crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain.
DC28246 EMPA EMPA is a high-affinity, reversible and selective orexin OX2 receptor antagonist. [3H]EMPA binds to human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nM respectively.
DC9573 SB-674042 SB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM); exhibits 100-fold selectivity for OX1 over OX2 receptors.
DC7277 SB-408124 SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively; exhibits 50-fold selectivity over OX2 receptor.
DC8419 SB-334867 SB-334867 is a selective orexin-1 (OX1) receptor antagonist.
DC7495 SB-334867 HCl SB-334867 is a selective non-peptide orexin OX1 receptor antagonist with a pKb value of 7.2.
DC11439 Nemorexant ACT-541468 is a dual orexin receptor antagonist.
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