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Vevorisertib trihydrochloride

  Cat. No.:  DC47763   Featured
Chemical Structure
1416775-08-0
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Field of application
Vevorisertib (ARQ 751) (trihydrochloride) is an orally active, potent and selective pan-AKT serine/threonine kinase inhibitor against AKT1 (IC50=0.55 nM), AKT2 (IC50=0.81 nM), and AKT3 (IC50=1.31 nM). Vevorisertib (trihydrochloride), as a single agent or in combination with other anti-cancer agents, can be used for the research of solid tumors with PIK3CA / AKT / PTEN mutations.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1416775-08-0
Chemical Name: Acetamide, N-[1-[3-[3-[4-(1-aminocyclobutyl)phenyl]-2-(2-amino-3-pyridinyl)-3H-imidazo[4,5-b]pyridin-5-yl]phenyl]-4-piperidinyl]-N-methyl-, hydrochloride (1:3)
Synonyms: Acetamide, N-[1-[3-[3-[4-(1-aminocyclobutyl)phenyl]-2-(2-amino-3-pyridinyl)-3H-imidazo[4,5-b]pyridin-5-yl]phenyl]-4-piperidinyl]-N-methyl-, hydrochloride (1:3);Vevorisertib trihydrochloride;AKOS040756749;DA-78869;HY-137458A;CS-0226602;ARQ 751 (trihydrochloride);HNFNJTGXAZHZSB-UHFFFAOYSA-N;1416775-08-0;MS-31155;Vevorisertib (trihydrochloride);N-[1-(3-{3-[4-(1-aminocyclobutyl)phenyl]-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-5-yl}phenyl)piperidin-4-yl]-N-methylacetamide trihydrochloride
SMILES: NC1N=CC=CC=1C1=NC2=CC=C(C3C=CC=C(N4CCC(N(C)C(=O)C)CC4)C=3)N=C2N1C1C=CC(C2(CCC2)N)=CC=1.Cl.Cl.Cl
Formula: C35H41Cl3N8O
M.Wt: 696.1
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_31613_DC47763_1416775-08-0
COA
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Cat. No. Product name Field of application
DC47763 Vevorisertib trihydrochloride Vevorisertib (ARQ 751) (trihydrochloride) is an orally active, potent and selective pan-AKT serine/threonine kinase inhibitor against AKT1 (IC50=0.55 nM), AKT2 (IC50=0.81 nM), and AKT3 (IC50=1.31 nM). Vevorisertib (trihydrochloride), as a single agent or in combination with other anti-cancer agents, can be used for the research of solid tumors with PIK3CA / AKT / PTEN mutations.
DC10055 Akt-I-1,2 HCl The compound (Akt-I-1,2) inhibited both Akt1 and Akt2 with IC50 values of 2.7 and 21 μM respectively.
DC2070 GSK690693 GSK690693 is a pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 2 nM, 13 nM, and 9 nM, respectively.
DC10408 BAY1125976 BAY1125976 is a selective allosteric Akt1/2 inhibitor; inhibits Akt1 and Akt2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively.
DC9972 ARQ-092(Miransertib) ARQ 092 is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3).
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