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VU0469650

  Cat. No.:  DC71342   Featured
Chemical Structure
1443748-47-7
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More than 5000 active chemicals with high quality for research!
Field of application
VU0469650 is a potent, selective and CNS-penetrated negative allosteric modulator of mGlu1 receptor, with an IC50 of 99 nM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1443748-47-7
Chemical Name: 3-[(3R)-4-(Adamantane-1-carbonyl)-3-methylpiperazin-1-yl]pyridine-2-carbonitrile
Synonyms: VU 0469650 hydrochloride;VU 0469650;BDBM50436506;3-[(3R)-4-(Adamantane-1-carbonyl)-3-methylpiperazin-1-yl]pyridine-2-carbonitrile;CS-0033055;3-[(3R)-4-(adamantane-1-carbonyl)-3-methylpiperazin-1-yl]pyridine-2-carbonitrile;VU0469650;(R)-3-[4-(Adamantane-1-carbonyl)-3-methyl-piperazin-1-yl]-pyridine-2-carbonitrile;TS-08656;HY-110191;CHEMBL2397347;AKOS040749761;GLXC-03588;2-Pyridinecarbonitrile, 3-[(3R)-3-methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]-;1443748-47-7
SMILES: O=C(C12CC3CC(CC(C3)C1)C2)N1CCN(C2C(C#N)=NC=CC=2)C[C@H]1C
Formula: C22H28N4O
M.Wt: 364.483924865723
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC73469 ML353 ML353 (VU0478006) is a highly potent, selective, MPEP-site silent allosteric modulator of mGlu5 receptor with with sub-100 nM affinity.
DC71342 VU0469650 VU0469650 is a potent, selective and CNS-penetrated negative allosteric modulator of mGlu1 receptor, with an IC50 of 99 nM.
DC49647 MNI137 MNI137 is a potent and selective negative allosteric modulator for group II mGluRs. MNI137 has IC50s values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization.
DC44955 RO0711401 RO0711401 is a selective and orally active positive allosteric modulator of mGlu1 receptor with an EC50 of 56 nM.
DC28990 Decoglurant Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3. Decoglurant is developed as an antidepressant.
DC28980 Biphenylindanone A Biphenylindanone A (BINA) is a selective human mGluR2 (hmGluR2) potentiator for the treatment of many neurological disorders.
DC28200 LY367385 LY367385 is a highly potent and selective mGluR1a antagonist. LY367385 has an IC50 of 8.8 μM for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with > 100 μM for mGlu5a. LY367385 has neuroprotective, anticonvulsant and antiepileptic effects.
DC11437 VU0652957 VU0652957 (VU2957, Valiglurax) is a potent, selective mGlu4 positive allosteric modulator (PAM) with EC50 of 64.6 nM in calcium mobilization human mGlu4/Gqi5 assays; showes excellent pharmacokinetics across species (low CLps, %F > 35%), an acceptable CYP profile (>30 uM vs. 3A4, 2D6 and 2C9, 12.5 uM vs. 2C19 and 1.5 uM vs. 1A2), no CYP induction or timedependent inhibition and excellent metabolite coverage across species; also shows attractive predicted human PK parameters (CLps 5-9 mL/min/kg, Vds 1-2 L/kg and t1/2 2-4 hours).
DC7843 JNJ 42153605 JNJ 42153605 is a positive allosteric modulator of the metabotropic glutamate 2 receptor.
DC7016 JNJ40411813 For the detailed information of JNJ40411813, the solubility of JNJ40411813 in water, the solubility of JNJ40411813 in DMSO, the solubility of JNJ40411813 in PBS buffer, the animal experiment (test) of JNJ40411813, the cell expriment (test) of JNJ40411813, the in vivo, in vitro and clinical trial test of JNJ40411813, the EC50, IC50,and Affinity of JNJ40411813, Please contact DC Chemicals..
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