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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC22032 BMS-211
BMS-211 is a prodrug of the parent pan-CK2 inhibitor BMS-699..
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DC8515 BMS-2
BMS-2 is a potent MET kinase inhibitor with an IC50 value of 1.8nM. It also possesses potent inhibitory activity against Flt-3 and VEGFR-2 kinases, IC50 values of 4nM and 27nM respectively.
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DC11761 BMS-816336
A novel potent, selective, orally active human 11β-HSD1 inhibitor with IC50 of 3.0 nM.
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DC20812 BMS 695735
BMS 695735 is a potent, selective IGF-1R inhibitor with IC50 of 34 nM.
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DC8452 BMN-673 8R,9S
BMN-673 (8R,9S) is the (8R,9S) enantiomer of BMN-673. BMN 673 is a novel PARP inhibitor with IC50 of 0.58 nM(PARP1). It does not inhibit PARG and is highly sensitive to PTEN mutation.
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DC20321 Bm-MPK1-IN-15b
Bm-MPK1-IN-15b is a potent, orally bioavailable inhibitor of B. malayi stress-activated kinase Bm-MPK1 with IC50 of 24 nM.
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DC23304 BM-957
BM-957 is a highly potent, dual Bcl-2 and Bcl-xL inhibitor with Ki of <1 nM for both, IC50 of 5.4 and 6.0 nM, respectively.
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DC20802 BM-635
BM-635 is a small molecule anti-mycobacterial compound acting by inhibiting the mycobacterial membrane protein Large 3 (MmpL3).
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DC23305 BM-1197
BM-1197 is a potent, specific dual inhibitor of Bcl-2 and Bcl-xL with Ki of <1 nM, shows >1,000-fold selectivity over Mcl-1.
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DC12650 BLU-667 trans form
BLU-667 trans form is the trans form of BLU-667, which is a highly potent, selective, next generation RET inhibitor..
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DC7087 Blonanserin(AD-5423)
Blonanserin(AD-5423) is a D2/5-HT2 receptor antagonist, atypical antipsychotic.
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DC23439 BL-1020
BL-1020 is an ester of GABA and perphenazine, fuctions as orally-active antipsychotic agent and acts as a D2 antagonist and GABA agonist.
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DC20739 BJE6-106
BJE6-106 (B106) is a potent, selective PKCδ inhibitor with IC50 of 50 nM, displays excellent selectivity over classical PKC isozymes (a 1,000-fold PKCδ selectivity over PKCα).
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DC23383 Bizine
Bizine is a phenelzine analog that inhibits LSD1 with Ki of 59 nM, displays 23-fold, 63-fold, and >100-fold selectivity for LSD-1 over MAOA, MAOB, and LSD2 respectively.
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DC5003 BIX02189 (BIX 02189)
BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.
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DC11307 Bitertanol
Bitertanol is a broad-spectrum triazole fungicide that is active against a variety of fungi, including V. inaequalis and V. pirina.
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DC21599 Bis-T-23
Bis-T-23 is a small molecule that stimulates actin-dependent dynamin oligomerization and promotes dynamin GTPase activity, increases actin polymerization in injured podocytes.
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DC20212 Bisphenol A
Bisphenol A is a starting material for the synthesis of plastics, primarily certain polycarbonates and epoxy resins, as well as some polysulfones and certain niche materials. It exhibits estrogen-mimicking, hormone-like properties.
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DC20798 Bisperoxovanadium
Bisperoxovanadium (bpV(phen) potassium hydrate) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 =38 nM), also inhibits the vascular endothelial PTP, PTP-β (IC50=3
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DC20320 Bio-AMS
Bio-AMS is a chemical inhibitor of Mycobacterium tuberculosis biotin protein ligase ( MtBPL) with Kd of 0.865 nM.
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DC12401 BIO922
BIO922 (BIO 922, BIO-922) is a small molecule PICK1 inhibitor that specificly blocks the PDZ domain-mediated interaction between GluA2 and PICK1 (IC50=69 nM), blocks the effects of Aβ on synaptic transmission and surface receptors.
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DC11069 BIO124
BIO124 (BIO-124) is a modest inhibitor of the PICK1-GluA2 interaction with IC50 of 0.51 uM in FP assays, binds to the PDZ domain of PICK1..
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DC11178 BIO1211
BIO1211 (BIO-1211) is a potent, highly specific integrin α4β1 (VLA-4) inhibitor with Kd/IC50 of 20 pM/4 nM for the activated form of α4β1.
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DC20795 BIO 8898
BIO 8898 is a synthetic, CD40-CD154 co-stimulatory interaction inhibitor that inhibits the TNF family cytokine CD40L binding to CD40-Ig with a potency of IC50=25 uM.
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DC20793 BILH-434
BILH-434 is a potent HPV11 E1/E2/DNA complex inhibitor that binds to the transactivation domain (TAD) of E2 protein with a Kd of 40 nM, has an IC50 of 180 nM in the E1-E2-ori complex formation assay..
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DC20791 BIIL260
BIIL260 is the active metabolite of BIIL284, shows high affinity to LTB4 receptor on isolated human neutrophil cell membranes with Ki of 1.7 nM.
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DC10393 Bicyclomycin benzoate
Bicyclomycin benzoate is an antibiotic exhibiting activity against a broad spectrum of Gram-negative bacteria and against the Gram-positive bacterium.
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DC20790 BIBU1361 dihydrochloride
BIBU1361 is a potent, selective, orally active EGFR inhibitor with IC50 of 3 nM, shows weak activity against HER2 (IC50=280 nM) and no inhibition on IGF1R, HGFR, Src, and VEGFR2 (IC50>10 uM).
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DC20789 BIBU1361
BIBU1361 is a potent, selective, orally active EGFR inhibitor with IC50 of 3 nM, shows weak activity against HER2 (IC50=280 nM) and no inhibition on IGF1R, HGFR, Src, and VEGFR2 (IC50>10 uM).
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DC12211 BIBR 1087 SE (Desethyl Dabigatran Etexilate)
BIBR 1087 SE is an intermediate metabolite of dabigatran etexilate.
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