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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC20797 BF 844
BF 844 (BioFocus 844) is a small molecules capable of stabilizing mutant USH3 mutation CLRN1(N48K).
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DC11567 BETd-260 trifluoroacetate
BETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL.
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DC8556 BET-BAY 002
BET-BAY 002 is a potent BET inhibitor; shows efficacy in a multiple myeloma model.
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DC12320 Betanin
Betanin has potent antioxidant and anti-inflammatory effect, that could inhibit peroxynitrite (ONOO-), with an IC50 of 19.2 μM. Betanin is a red glycoside obtained from beets that can be used as colorant.
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DC11042 BET inhibitor CF53
BET inhibitor CF53 is a highly potent, orally active inhibitor of bromodomain and extra-terminal (BET) with Ki of <1 nM (BRD4 BD1).
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DC21519 Besifovir
Besifovir (PMCDG Dipivoxil, NA-380, LB-80380) is a potent, selective, orally available anti-HBV agent, the prodrug of PMCDG (EC50=4 uM)..
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DC21868 Berotralstat
Berotralstat is a potent human plasma kallikrein inhibitor.
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DC22478 Bephenium
Bephenium is an anthelmintic compound that acts as an activiator of nematode B-type nAChR, is used in the treatment of hookworm infections and ascariasis..
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DC22482 Bephenium hydroxynaphthoate
Bephenium hydroxynaphthoate is an anthelmintic compound that acts as an activiator of nematode B-type nAChR, is used in the treatment of hookworm infections and ascariasis..
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DC20216 Benzylcetyldimethylammonium chloride hydrate
Benzylcetyldimethylammonium chloride hydrate is a chemical.
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DC12173 Benzyl alcohol (Benzenemethanol)
Benzyl alcohol is an aromatic alcohol; a colorless liquid with a mild pleasant aromatic odor.
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DC9885 Benzenesulfonamide
Benzenesulfonamide ia an inhibitor of carbonic anhydrases
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DC22184 Benzarone
Benzarone (NSC 82134) is a small molecule inhibitor of Eyes Absen (EYA) protein tyrosine phosphatase activity (IC50=17 uM, EYA3), exhibits selectivity for EYA over PTP1B.
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DC20185 Benzamidine HCl
Benzamidine is an inhibitor of serine proteases with Ki values of 35, 350, and 220 µM for trypsin, plasmin, and thrombin, respectively.
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DC12299 Benfluralin
Benfluralin is a kind of herbicide and an agrochemical which can be used as a pre-emergence herbicide used for the control of grass and other weeds in a range of food and non-food crops.
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DC20135 Bemesetron (MDL 72222)
Bemesetron (MDL 72222) is a selective 5-HT3 receptor antagonist with an IC50 of 0.33 nM. Neuroprotective effect.
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DC8160 ZGN-440(Beloranib)
Beloranib is being studied as a first-in-class obesity therapy that demonstrates a unique mechanism of action through methionine aminopeptidase 2 (MetAP2 ) inhibition.
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DC20030 Begacestat (GSI-953)
Begacestat (GSI-953) is a selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase (IC50Aβ40=15 nM) for the treatment of Alzheimer's disease.
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DC20668 Becampanel
Becampanel (AMP 397) potent, competitive antagonist of the AMPA receptor (AMPAR) with IC50 of 11 nM.
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DC20319 Beauvericin
Beauvericin is a cyclic hexadepsipeptide with antibiotic and insecticidal effects, shows activity against Gram-positive bacteria and mycobacteria, and is also capable of inducing programmed cell death in mammals..
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DC12596 BDP-NAC
BDP-NAC is a novel persulfide donor that shows selectivity towards H2 O2 over other potential oxidative or nucleophilic triggers, resulting in the sustained release of the persulfide of N-acetyl cysteine (NAC).
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DC23980 BCX-1470
BCX-1470 (BCX1470) is a serine protease inhibitor that inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM).
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DC20761 BCM-599
BCM-599 is an efficient HBV capsid assembly inhibitor with in vitro IC50 of 13 uM, shows synergistic inhibitory effects on decreasing viral concentration combined with lamivudine in vivo..
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DC20760 BCL6-IN-8
BCL6-IN-8 (BCL6-i) is a potent, irreversible and cell-active BCL6 inhibitor with inact/KI value of 1.9 × 104 M-1 s-1, targets Cys53 located at the protein-protein interaction interface.
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DC12447 BCL6 PROTAC 15
BCL6 PROTAC 15 is a novel B-cell lymphoma 6 (BCL6) PROTAC, significantly degrade BCL6 in a number of DLBCL cell lines, but neither BCL6 inhibition nor degradation selectively induces marked phenotypic response.
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DC12446 BCL6 inhibitor 14
BCL6 inhibitor 14 is a potent BCL-6 inhibitor with FRET IC50 of 63 nM..
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DC20758 BCI-137
BCI-137 is a chemical compound able to compete with Argonaute 2 miRNAs binding, binds to Ago2 with Kd of 126 uM.
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DC20757 BC-23
BC-23 (NSC 45382) is a novel inhibitor of β-catenin/Tcf4 interaction with IC50 of 1.7 uM.
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DC21401 BC-21
BC-21 (NSC 109268) is a novel small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 6.55 uM.
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DC20755 BC-1485
BC-1485 is a first-in-class, small molecule inhibitor of FIEL1 (Fibrosis-inducing E3 ligase 1) that exhibits potent activity toward disrupting FIEL1-directed PIAS4 ubiquitination.
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