Antibiotic enhancer against resistant Gram-negative bacteria

Selective kynurenine-3-hydroxylase inhibitor

Novel potent and selective inhibitor of human DNA polymerase kappa (hpol κ)

Novel potent and selective inhibitor of fat mass obesity-associated protein (FTO), being selectively over alkylation repair homologue 5 (ALKBH5), another DNA/RNA demethylase

Novel analogue of combretastatin A-4, enhancing connexin43 expression

Natural antagonist of serotonergic receptors and inhibitor of CDK5/p25 and GSK-3ß

Novel anticancer agent, inhibiting lung cancer cell proliferation via a PKCa and ERK1/2 dependent mechanism

Natural antioxidant and anti-cancer agent, blocking the MAPK/NF-κB and activating Nrf2/HO-1

Novel selective r(CGG)exp probe, improving pre-mRNA splicing defects, inhibiting formation of nuclear inclusions and RANT in a FXTAS cellular model

Novel potent and selective inhibitor of Schistosoma mansoni dihydroorotate dehydrogenase (SmDHODH)

Novel multitarget Fasudil derivative, inducing the NRF2 signature, promoting the expression of the antioxidant response enzymes HO-1 and NQO1, via a KEAP1-dependent mechanism

Activable Probe for Noninvasive Hydroxyl Radical Imaging, emitted in 1000-1400 nm after responding to ·OH

Inhibitor of apurinic endonuclease-1 (APE1) by direct protein binding

Novel CK2-Specific Pt(II) Compound, Reversing Cisplatin-Induced Resistance by Inhibiting Cancer Cell Stemness and Suppressing DNA Damage Repair in Non-small Cell Lung Cancer Treatments

Novel human antigen R (HuR) ligand, acting as a HuR-RNA interferer

Adhesive peptide (sequence 351-359 mapped on the Human Vitronectin Protein), covalent and selective functionalizing on glass and titanium surfaces, increasng osteoblast attachment and adhesion strength and to promoting osseointegration

Novel analgesic agent, activating TRPA1 and subsequently desensitizing the channel, exhibiting higher inhibitory activity than resveratrol

Novel activator of PC2

Novel, potent, selective, and orally efficacious dual antagonist of the orexin receptors

Novel allosteric antagonist of the glucagon-like peptide-1 receptor (GLP-1R)

Novel macrocyclic calcitonin gene-related peptide (CGRP) receptor antagonist

Novel macrocyclic calcitonin gene-related peptide (CGRP) receptor antagonist

Novel heat shock protein 90 (Hsp90), more potent enantiomer

Novel heat shock protein 90 (Hsp90) inhibitor

Novel potent inhibitor of heat shock protein 90 (Hsp90), effectively reducing the expression levels of Hsp90 client proteins including Her2, EGFR, Met, Akt, and c-Raf

Novel Hsp90-Aha1 chaperone complex formation inhibitor, enhancing F508del-CFTR channel activity

Novel inhibitor of heat shock 27 kDa protein (HSP27), significantly inducing AR degradation in GBM cells via the proteasomal pathway, selectively inhibiting AR-overexpressed GBM cell growth with IC 50 values around 5 nM

Novel Peripherally-Restricted Kappa Opioid Receptor (KOR) Agonist with Antinociceptive and Antipruritic Effects

Novel inhibitor of lipoteichoic acid (LTA) biosynthesis, potently inhibiting S. aureus and E. faecalis growth and biofilm formation

Novel potent inhibitor of the recombinant FLT3 kinase and its mutant forms, blocking the proliferation of AML cell lines, harboring oncogenic FLT3-ITD mutations with remarkable IC50 values, which were comparable to the approved FLT3 inhibitor quizartinib,