Novel lysine specific histone demethylase 1 (LSD1) inhibitor, exhibiting high selectivity to LSD1 over MAOs

Novel selective non-imidazole histamine H 3 receptor antagonist

Novel agonist of toll-like receptor 2 (TLR2), stimulating the release of G-CSF in activated THP-1 cells, peripheral blood mononuclear cells, and human umbilical vein endothelial cells

Promiscuous kinase inhibitor, a close analog of CTx-0294885

Novel selective inhibitor of G protein-coupled receptor kinase 2 (GRK2)

Potent and selective antagonist of P2X7 receptor

Novel potent RORγ inverse agonist

Novel quaternized GSK-3008348 derivative, acting as a highly selective αvβ6 Integrin Inhibitor

Novel inhbitor of protein kinase GRK1/2/5 and PKA

Novel human immune virus (HIV) maturation inhibitor

Novel potent and selective, SAM-competitive inhibitor of SMYD3

Novel selective inhibitor of G protein-coupled receptor kinase 2 (GRK2)

Betulin derivative as antitumor agent

Specific ATPase competitive kinesin-5 inhibitor

Novel selective histamine H3 receptor antagonist

Novel I-kappa-B kinase-3 (IKK3) inhibitor

Novel S1P1 receptor agonist

Novel highly potent, reversible soluble epoxide hydrolase (sEH) inhibitor, exhibiting potent cell-based activity, a concentration-dependent inhibition of the conversion of 14,15-EET to 14,15-DHET, attenuating cigarette smoke-induced inflammation by both i

Selective inhibitor of iE-DAP-stimulated IL-8 release via the NOD1 signaling pathway

Inhibitor of insulin receptor, also tageting IGF-1R and ALK

Novel inhibitor of T. brucei IPMK, partially inhibiting rTbIPMK activity

Novel insulin-like growth factor 1 receptor inhibitor, binding to a novel region of the GRK active site cleft that could likely be exploited to achieve more selectivity

Novel AKT Inhibitor, Enhancing Anti-Tumor Effects in Combination with the MEK Inhibitor

Novel selective non-imidazole histamine H 3 receptor antagonist

Novel competitive inhibitor of rTbIPMK with respect to Ins(1,4,5)P3

Novel potent, metabolically stable and centrally penetrant PPARγ partial agonist

Novel inhibitor of EPHX2 (epoxide hydrolase 2, alias soluble epoxide hydrolase or sEH), up-regulating cytoprotective genes and down-regulating proinflammatory cytokine production

Potent and selective H3 histamine receptor inverse agonist

Potent non-cytotoxic inhinitor of Mycobacterium tuberculosis H37Rv

Novel noncompetitive inhibitor of rTbIPMK