Novel dual inhibitor of BPTF and Brd4

Novel specific P2X(7) receptor antagonist

Non-peptidic snail toxin; Activator of the Kv1.1 potassium ion channel

Novel allosteric inhibitor of human immunodeficiency virus (HIV) integrase, blocking viral replication and abnormal multimerization involving specific protein domains

Novel selective inhibitor of MmpL3 mutation

Potent and selective GPR119 agonist

Novel inhibitor of polo-like kinase

Novel inhibitor of polo-like kinase

Potent inhibitor of AKT kinase, showing activity against auxotrophic M. tuberculosis and being potentiated with meropenem

Novel dual H1 and H3 receptor antagonist with a long duration of action

Potent inhibitor of AKT kinase

Novel potent EchA6 inhibitor

Novel allosteric HIV-1 integrase (IN) inhibitor, disrupting formation of mature HIV particles

Glutamate receptor antagonist and radical scavenging agent

Novel high potent and selective stabilizer of the MYC G-quadruplex (G4)

Potent and selective inhibitor of HIV-1 protease, effectively inhibiting protease mutants with amino acid insertions, also inhibiting major aspartyl peptidase 1 (May1), a secreted Cryptococcus neoformans protease

Novel oral prodrug of GS-441524, inhibiting SARS-CoV-2, including variants of concern (VOC) in cell culture and human airway epithelium organoids

Novel Inhibitor of Hepatitis C Viral Infectivity

Novel potent inhibitor of feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies

Novel allosteric inhibitor of respiratory syncytial virus (RSV)

Novel β-Secretase BACE1 Inhibitor, reversing memory impairments and rescuing age-related cognitive decline

Novel CCR5 inhibitor, inhibiting the replication of wild-type R5-HIV-1

Novel, potent, and selective G protein-coupled receptor kinase 6 (GRK6) inhibitor with an IC50 value of 6 nM against GRK6 and selectivity against a panel of 85 kinases

Novel potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor

Natural Potent Inhibitor for Glioblastoma Stem Cell via Targeting RHOA and PI3K/AKT

Novel oral specific TRPV1 antagonist, decreasing bladder overactivity and noxious bladder input in cystitis animal models

Novel orally available, potent and selective inhibitor of Transient Receptor Potential Ankyrin 1 (TRPA1) with IC50 value less than 10 nM

Natural blocker of the voltage-gated sodium channels located in the cell membrane of neurons

Novel Nrf2 modulator via a thus far uncharacterized mechanism

Potent 5HT3 antagonist