Novel potent and selective covalent inhibitor of FGFR4 kinase

Novel, covalent, highly potent, and exquisitely specific FGFR4 inhibitor

Potent, reversible, ATP-competitive inhibitor against PDGFRβ, FGFR-1, and VEGFR-2 (IC50 = 20, 90, and 240 nM, respectively) and effectively suppresses VEGF-stimulated proliferation of HMVECs (EC50 = 420 nM).

Novel fluorescent probe as an excellent VMAT2 substrate capable of detecting VMAT2 activity in intact cells using fluorescence microscopy

Novel PAM-antagonist of the function of C3 at FFA3

Selective and moderately potent positive allosteric modular (PAM)-agonist of the FFA3 receptor

Selective orthosteric agonist of human FFA2

Natural potent colchicine site binding microtubule-destabilizing agent with anti-proliferation and anti-metastasis activity via PAK1 and p21-mediated signaling in breast cancer cells

Iron chelator, mediating iron transport in Streptomyces pilosus

Novel ferroptosis inducer, killing selected cancer cell lines by harnessing reactive oxygen species (ROS)

Novel oral iron therapy agent, being effective in correcting iron deficiency anemia in patients with inflammatory bowel disease

Non-steroidal antiinflammatory agent

Non-steroidal anti-inflammatory drug, being used for symptomatic relief for rheumatoid arthritis, osteoarthritis, and mild to moderate pain

Potent, selective, noncompetitive glutamate mGluR5 receptor antagonist

Novel potent antimalarial agent, binding to ferriprotoporphyrin-IX (FeIII-PPIX) (Kd = 33 nM) against chloroquine-resistant and sensitive strains of Plasmodium falciparum

Novel rapamycin derivative, targeting polycystic kidneys due to the high expression of the folate receptor (FRα), lacking the extra-renal effects of unconjugated rapamycin, in particular immunosuppressive effects

Novel phosphodiesterase 4 (PDE4) inhibitor with little emetic potential, blocking MPP+ induced oxidative damage in SH-SY5Y cells and neurons via AMPK-dependent autophagy

Specific inhibitor of inflammasome assembly, targeting the NLRP3 inflammasome by interfering with the proximity-induced autocleavage of procaspase-1

Novel CAIX inhibitor, inhibiting breast cancer invasion and metastasis

Novel potent αvβ3 antagonist. reducing GBM tumor growth and viability by up to 98%

First-in-class covalent allosteric inhibitor of fructose-1,6-bisphosphate aldolase (FBA) from Candida albicans (CaFBA)

Potent and selective dopamine D3 receptor partial agonist

Highly potent and selective dopamine D4 receptor agonist

Dopamine D4 receptor antagonist

Novel irreversible dopamine D2 receptor ligand, covalently binding the L94C mutant of the dopamine D2 receptor

Dopamine D4 receptor antagonist

Novel folate-targeted TLR7 agonist, selectively accumulating in profibrotic macrophages and suppressing fibrosis-inducing cytokine production, reprograming M2-like fibrosis-inducing macrophages into fibrosis-suppressing macrophages, resulting in dramatic

Novel fatty acid synthase (FASN)

Novel potent and specific fatty acid synthase (FASN) inhibitor

Novel inhibitor of C. difficile's FASII pathway