Novel potent and selective anti-Trypanosoma cruzi agent

Novel anticancer pan-JAK inhibitor against A2058 human melanoma cells, selective and potent inhibitor of JAK1 and TYK2

Estradiol derivative, showing antioxidant activity

Antiatherosclerotic, antihyperlipidemic, antiinflammatory, antifungal, antiviral and antineoplastic

Novel plant immunoregulator, being effective in delaying senescence in detached leaves while having low interactions with the cytokinin pathway, upregulating genes involved in processes associated with plant innate immunity such as cell wall remodeling an

Metabotropic glutamate I (mGlu1) receptor antagonist

Potent, ATP-competitive and reversible inhibitor of Akt1/2/3-as1/2 without inhibiting Akt1/2/3-wt

Novel GATA4-NKX2-5 transcriptional synergy activator, significantly enhancing the mechanical stretch-stimulated increase of the ANP mRNA levels

Novel Orally Active Antimalarials Targeting Plasmodium falciparum

Metabolite in the kynurenine pathway, the major route of tryptophan degradation in mammals

Major tryptophan catabolite of the kynurenine pathway, showing antiparasitic activity

Novel plant immunoregulator, being effective in delaying senescence in detached leaves while having low interactions with the cytokinin pathway, upregulating genes involved in processes associated with plant innate immunity such as cell wall remodeling an

Novel potent apoptotic inducer, inducing G2-M cell cycle arrest, blocking tubulin polymerization

Novel mammalian targeting potent inhibitor of rapamycin (mTOR) activation

Biological Active Reagents

Novel anti-Parkinson agent, targeting the D2R

Cell-permeable sialic acid analog, deacetylating intracellularly to a sialyltransferase inhibitor, abolishing SLex expression on HL-60 cells, reducing E-selectin and P-selectin binding and preventing metastasis formation in a mouse lung metastasis model

Novel inhibitor of 3C-like protease (3CLpro) of MERS-CoV and severe acute respiratory syndrome coronavirus (SARS-CoV)

The first-in-class triple topoisomerase I/topoisomerase II/tubulin inhibitor

Putative natural allosteric modulator of human Hsp90α conformational dynamics by allosteric ligand interaction at the C-terminal domain site 2

Potent endogenous estrogen

Tyrosine drivative, being a useful probe to study the role of redox active tyrosines in enzymes

Neuroprotective and proliferative agent with significantly higher stimulatory effect than that of allopregnanolone

Endogenous inhibitory androstane neurosteroid and weak androgen, and a major metabolite of dihydrotestosterone (DHT); Potent positive allosteric modulator of the GABAA receptor

SL0101 analog, acting as a specific inhibitor of p90 ribosomal S6 kinase (RSK), being approximately 2-fold more potent at inhibiting MCF-7 cell proliferation compared to SL0101 and preferentially decreased MCF-7 cell growth, as compared to the growth of t

Natural inducer of DNA damage, cell cycle arrest, apoptosis, and autophagy in macrophages

Natural potent, selective, and efficacious inhibitor of SHP2, suppressing A549 cell proliferation (IC 50 =10.79±0.14μM), invasion and inducing cell apoptosis through SHP2/ERK1/2 and SHP2/AKT pathways

Useful pharmaceutical building block

Metabolite of thyroid hormones (thyroxine and triiodo-L-thyronine)

Inhibitor of human tyrosyl-DNA phosphodiesterase 1 (TDP1)