Novel hemagglutinin (HA) protein inhibitor, inhibiting entry and replication of diverse influenza viruses via the HA protein, showing potent antiviral activity against diverse H1N1, H5N1, and H3N2 influenza viruses encoding HA proteins from both groups 1

Inhibitor of monoamine oxidase (MAO)

Novel inhibitor of STAT3 activation, inhibiting head and neck cancer cell proliferation in a dose dependent manner

Inhibitor of acetic acid-induced writhing response

Novel water-soluble and biocompatible small-molecule near-infrared II (NIR-II) fluorescent dye

Novel class of selective diacylglycerol acyltransferase 2 (DGAT2) inhibitor

Novel class of selective diacylglycerol acyltransferase 2 (DGAT2) inhibitor

Novel full H1 agonist

Novel Rho-associated coiled coil-formed protein kinase (ROCK) inhibitor, exerting strong intraocular pressure (IOP)-lowering effects into the eyes of monkeys

Novel Rho-associated coiled coil-formed protein kinase (ROCK) inhibitor, exerting strong intraocular pressure (IOP)-lowering effects into the eyes of monkeys

Novel bacterial DNA gyrase inhibitor, exhibiting antimicrobial activity and inhibiting bacterial cell division

AMPA antagonist

GX-936 analog, antagonist of voltage-gated sodium 1.7 (Nav1.7) channels

Novel potent inhibitor of NaV1.7 and highly selective against NaV1.5, having limited selectivity against NaV1.1 and NaV1.2

Novel inhibitor of Nav1.7

Novel NAD+-competitive Sirt2 inhibitor

Novel polo-like kinase (PLK1) inhibitor

Novel potent and selective inhibitor of the cytochrome bc1 complex of mitochondrial electron transport in P. falciparum

Novel inhibitor of mitosis and cytokinesis in T. brucei which causes human African trypanosomiasis (HAT)

Novel Inhibitor of GSK3beta

Potent GSK-3 inhibitor, highly selective over CDK-2

Novel and potent inhibitor of VEGFR2 tyrosine kinase, non-selectivey inhibiting AURKA and AURKB

Potent and selective inhibitor of glycogen synthase kinase 3 (GSK3)

Selective agonist of peroxisome proliferator-activated receptor-γ (PPARγ)

Selective cyclin dependent kinase inhibitor; Inhibitor of Yes1 kinase; Inhibitor of binding or entry into cells for Lassa Virus

Novel inhibitor of firefly luciferase derived from Photinus pyralis (FLuc), the most widely used luciferase

Novel inhibitor of EGFR

Potent inhibitor of PfDHODH, showing greater than 4,000-fold selectivity for the malarial enzyme

Novel VEGFR inhibitor, also a moderate inhibitor of BET proteins with an IC 50 value of 4.6 μM for BRD4(1)

Inhibitor of Mer Kinase, also inhibiting EGFR