K-Ras ligand-Linker Conjugate 2 incorporates a ligand for K-Ras, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 2 can be used in the synthesis of PROTAC K-Ras Degrader-1, which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells.

3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone. 3-Amino-2-oxazolidinone is always be detected as a indicator of furazolidone residues in vivo.

Mc-Dexamethasone is a drug-linker conjugate for ADC. Mc-Dexamethasone is made toxin Dexamethasone conjugated to the non-cleavable MC linker. Dexamethasone is a?glucocorticoid receptor?agonist.

N4-Acetylsulfamethoxazole (Acetylsulfamethoxazole) is a metabolite of Sulfamethoxazole. Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic, used for bacterial infections.

TL13-110 is a negative control for TL13-112 and a potent ALK inhibitor with an IC50 of 0.34 nM. TL13-110 does not degrade ALK in cells.

3-Amino-2-oxazolidinone-d4 is a deuterium labeled 3-Amino-2-oxazolidinone. 3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone. 3-Amino-2-oxazolidinone is always be detected as an indicator of furazolidone residues.

Demecycline, a tetracycline antibiotic, is the C6-demethylated derivative of Tetracycline against bacterial infections including pneumonia and other respiratory tract infections.

D-Valine is the enantiomer of L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid.

(S)-(+)-O-Desmethyl Venlafaxine is a S-enantiomer of O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine. Venlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.

(S)-O-Desmethyl Venlafaxine N-Oxide is a N-oxyde of (S)-O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine. Venlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.

(R)-(-)-O-Desmethyl Venlafaxine D6 is the deuterium labeled (R)-(-)-O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine. Venlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.

(S)-(+)-O-Desmethyl Venlafaxine D6 is the deuterium labeled (S)-(+)-O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine. Venlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.

Dasatinib metabolite M6 (Dasatinib carboxylic acid) is an oxidative metabolite of Dasatinib. Dasatinib is a potent and orally active dual Bcr-Abl and Src family tyrosine kinase.

Sarafotoxin S6a TFA , a sarafotoxin analogue, is a endothelin receptor agonist and has an ETA/ETB selectivity profile similar to that of Endothelin-3. Sarafotoxin S6a TFA elicits the pig coronary artery with an EC50 value of 7.5 nM.

17-DMAP-GA, a Geldanamycin analogue, is an inhibitor of HSP90. 17-DMAP-GA causes cell cycle abnormalities.

exo-IWR-1, an inactive stereoisomer of Endo-IWR-1, is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.

Sarafotoxin S6a, a sarafotoxin analogue, is a endothelin receptor agonist and has an ETA/ETB selectivity profile similar to that of Endothelin-3. Sarafotoxin S6a elicits the pig coronary artery with an EC50 value of 7.5 nM.

Homobaldrinal is a decomposition product of Valepotriate. Homobaldrinal exhibits genotoxic activity in the Salmonella/microsome test.

Cortisol sulfate sodium (Cortisol 21-sulfate) is a metabolite of Cortisol. Cortisol sulfate sodium is a specific ligand for intracellular transcortin.

Piperidine-GNE-049-N-Boc is a ligand for target protein for PROTAC of dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP.

Thalidomide-NH-PEG4-COOH is an E3 ligase ligand-linker conjugate which can be used for synthesizing dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP.

Necroptosis-IN-1, an analog of Necrostatin-1, is a potent necroptosi inhibitor. Necroptosis-IN-1 is a RIPK inhibitor.

Proguanil hydrochloride, an antimalarial prodrug, is metabolized to the active metabolite Cycloguanil. Proguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor.

Cortisol sulfate (Cortisol 21-sulfate) is a metabolite of Cortisol. Cortisol sulfate is a specific ligand for intracellular transcortin.

Sulfadiazine-13C6 is a labeled Sulfadiazine. Sulfadiazine is a sulfonamide antibiotic with antimalarial activity.

(E/Z)-AG490 ((E/Z)-Tyrphostin AG490) is a racemic compound of (E)-AG490 and (Z)-AG490 isomers. (E)-AG490 is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.

VHL Ligand-Linker Conjugates 17 incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. VHL Ligand-Linker Conjugates 17 can be used in the synthesis of a series of PROTACs, such as ARD-266. ARD-266 is a highly potent androgen receptor (AR) PROTAC degrader.

Vat Blue 2, a indigo derivative, is a dark blue 5,5'-dibromo-4,4'-dichloroindigo dye.

5-HT1A modulator 2 hydrochloride, a derivative of 8-OH-DPAT, is a modulator of 5-HT1A with a Ki of 53 nM for 5-HT1A binding.

N-Desmethyl imatinib mesylate (Norimatinib mesylate) is a metabolite of Imatinib. Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR.