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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC47118 Polyketide synthase 13-IN-3
Polyketide synthase 13-IN-3 (compound 41) is a polyketide synthase 13 inhibitor,with a MIC of 0.0625-0.125 μg/mL against the M. tuberculosis strain H37Rv.
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DC47116 Deutarserine
Deutarserine is a deuterium modified analog of endogenous D-serine (CTP 692), which is used in the research of adults with schizophrenia.
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DC47115 Befotertinib
Befotertinib (D-0316) is the third-generation EGFR tyrosine kinase inhibitor. Befotertinib can be used for the research of EGFR T790M-positive non-small cell lung cancer (NSCLC).
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DC47114 MurA-IN-1
MurA-IN-1 (compound 1a) is a PTPRR inhibitor, with IC50 values of 0.23 μM, 0.8 μM, 0.75 μM and 0.09 μM for PTP1B, PTPN5, PTPN7 and PTPRR, respectively. (A family of human MAPK-specific protein tyrosine phosphatases)
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DC47112 Afimetoran
Afimetoran is a toll-like receptor antagonist, which can be used in the research of inflammatory and autoimmune diseases.
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DC47111 Ecubectedin
Ecubectedin is a derivative. Ecteinascidins is a family of tetrahydroisoquinoline alkaloids with wide range of antitumor and antimicrobial activities.
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DC47110 Deudomperidone
Domperidone-d4 is a deuterium labeled Domperidone (R33812).Domperidone is a selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine.
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DC47109 Cimpuciclib
Cimpuciclib is a cyclin-dependent kinase(CDK) inhibitor and antineoplastic.
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DC47107 14-Deoxy-11-oxoandrographolide
14-Deoxy-11-oxoandrographolide is an antileishmanial agent. 14-Deoxy-11-oxoandrographolide inhibits the replication of heal chikungunya virus (CHIKV) and can be used for CHIKV infection research.
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DC47106 [18F]-Labeled L-dopa precursor
[18F]-Labeled L-dopa precursor is a precursor for synthesis of 18F-labeled L-dopa extracted from patent WO2014095739A1, example 8.
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DC47105 Complanatoside B
Complanatoside B is a P. chinense Fisch flavonoid with potential anti-inflammatory effects.
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DC47104 1,2-Dilauroyl-sn-glycero-3-phosphocholine
1,2-Dilauroyl-sn-glycero-3-phosphocholine (DLPC) is an LRH-1 agonist ligand. 1,2-Dilauroyl-sn-glycero-3-phosphocholine is a phospholipid for biological study.
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DC47103 SB 202474
SB 202474, a negative analog of SB203580. SB 202474, which has no ability to inhibit p38 MAPK activity and is widely used as a negative control compound in p38 MAPK studies, also suppressed melanin synthesis induction.
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DC47102 SSAO inhibitor-1
SSAO inhibitor-1 is a semicarbazide-sensitive amine oxidase (SSAO) inhibitor. SSAO inhibitor-1 has anti-inflammatory activity and can be used for liver diseases research.
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DC47101 γ-Linolenic acid ethyl ester
γ-Linolenic acid ethyl ester (Ethyl γ-linolenate) is a leukotriene B4 receptor 4 (LTB4) antagonist.
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DC47100 MARK-IN-4
MARK-IN-4 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of 1 nM. Inhibition of microtubule affinity regulating kinase (MARK) represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer's disease.
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DC47099 (Rac)-Golgicide A
(Rac)-Golgicide A ((Rac)-GCA) is a racemate of Golgicide A. Golgicide A (GCA) is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF) GBF1.Golgicide A drastically reduced replication of coxsackievirus B3 (CVB3) and other human enterovirus species.
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DC47098 KDM2B-IN-1
KDM2B-IN-1 is a histone demethylase (kdm2b) inhibitor and can be used for hyperproliferative diseases research.
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DC47097 Navafenterol saccharinate
Navafenterol (AZD-8871) saccharinate is an inhaled, long-acting bronchodilator, which is a muscarinic antagonist and β2 agonist.
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DC47096 Umckalin
Umckalin is a oxygenated coumarin from Pelargonium sidoides.
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DC47095 Larsucosterol sodium
Larsucosterol sodium is a cholesterol metabolite from the nuclei of normal human liver tissues, epigenetically regulates the transcription of proteins and enzymes involved in lipid synthesis, inflammation, and apoptosis.
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DC47092 Lazuvapagon
Lazuvapagon is a vasopressin V2 receptor agonist for the research of nocturia.
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DC47091 Guretolimod
Guretolimod is a Toll-like receptor 7 (TLR7) agonist.
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DC47089 Treprostinil palmitil
Treprostinil palmitil (TP) is the prodrug of DP1 and EP2 agonist, Treprostinil (UT-15), whose EC50 values were 0.6 and 6.2 nM, respectively. Treprostinil palmitil is a pure prodrug and possesses no inherent binding to G-protein coupled receptors including prostanoid receptors.
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DC47088 Amdizalisib
Amdizalisib is a PI3K inhibitor and used for the research of inflammatory disease, autoimmune disease or cancer.
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DC47087 Orismilast
Orismilast (LEO-32731) is a PDE4 inhibitor used for the research of inflammatory diseases.
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DC47086 7,3′,4′-Tri-O-methyleriodictyol
7,3′,4′-Tri-O-methyleriodictyol is a flavonoid with an antimutagenic activity. 7,3′,4′-Tri-O-methyleriodictyol inhibits the furylfuramide-induced SOS response and has potency as bioantimutagens.
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DC47085 AZD-CO-Ph-PEG4-Ph-CO-AZD
AZD-CO-Ph-PEG4-Ph-CO-AZD is a bis-β-lactam linker can be used for antibody-siRNA conjugate synthesis.
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DC47083 Exaluren
Exaluren (ELX-02) is an synthetic eukaryotic ribosome-selective glycoside that induces read through of nonsense mutations, resulting in normally localized full-length functional proteins. Exaluren is used for the research of cystic fibrosis caused by nonsense mutations.
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DC47082 Zelquistinel
Zelquistinel is a N-methyl-D-aspartate (NMDA) receptor partial agonist used for the research of depression, anxiety and other related psychiatric disorders.
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