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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC81642 Tilnoprofenic acid
Tilnoprofenic acid (Y-9223) is a Y-23023 metabolite, cyclo-oxygenase inhibitor. Tilnoprofenic acid inhibits IL-6 production. Tilnoprofenic acid can be used in the research of blood disorders.
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DC81641 Tilnoprofen arbamel
Tilnoprofen arbamel is a biochemical reagent.
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DC81640 Ticagrelor acetonide
Ticagrelor acetonide (Isopropylidene ticagrelor) (Compound 7) is a drug intermediate that can be used for the synthesis of lysine-specific demethylase (LSD1) inhibitors.
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DC81639 Tiadenol
Tiadenol is an absorbable hypolipidemic agent. Tiadenol can effectively reduce triglycerides and decrease the level of apolipoprotein E in very low-density lipoproteins in hyperlipoproteinemia. Tiadenol causes hepatomegaly in rats and affects their hepatic lipid levels, cholesterol synthesis and absorption at high doses. Tiadenol can be used in the research of endocrine and metabolic diseases such as hyperlipidemia.
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DC81638 THR-β modulator-3
THR-β modulator-3 (Compound 75-2) is a THR-β modulator. THR-β modulator-3reduces total fat mass, body weight. THR-β modulator-3 improves obesity.
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DC81637 Thioaspirine
Thioaspirine is a carbonic anhydrase (CA) inhibitor with Kis of 64.3 and 10.9 μM for hCA II and hCA IX, respectively. Thioaspirine effectively relieves the inflammatory pain in CFA-treated mice. Thioaspirine can be used for inflammatory pain research.
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DC81636 Thalidomide-azetidine-COOH
Thalidomide-azetidine-COOH is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.
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DC81635 Thalidomide-5-NH-C9-acid
Thalidomide-5-NH-C9-acid is a synthetic E3 ligase ligand-linker conjugate containing a Thalidomide-based Cereblon ligand and one linker.
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DC81634 Thalidomide-5-F-6-piperidinylpiperazin
Thalidomide-5-F-6-piperidinylpiperazin is an ligands for E3 ligase-linker conjugate, which is used for the synthesis of PROTAC CDK9 degrader-9.
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DC81633 Thalidomide-4-O-C9-Br
Thalidomide-4-O-C9-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based CRBN ligand and a linker used in PROTAC technology. Thalidomide-4-O-C9-Br can be connected to the ligand for protein by a linker to form PROTAC EZH2 Degrader-19.
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DC81632 Thalidomide-4-O-C11-Br
Thalidomide-4-O-C11-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based CRBN ligand and a linker used in PROTAC technology. Thalidomide-4-O-C11-Br can be connected to the ligand for protein by a linker to form PROTAC EZH2 Degrader-23.
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DC81631 TGR5 agonist 10
TGR5 agonist 10 is a selective, allosteric and orally active Takeda G protein coupled receptor 5 (TGR5) agonist with EC50s of 0.8 μM and 0.6 μM for human TGR5 and mouse TGR5, respectively. TGR5 agonist 10 demonstrates selectivity for TGR5 over FXR. TGR5 agonist 10 activates hTGR5 and mTGR5 to induce cAMP accumulation, and positively modulates lithocholic acid functional activity and potency at hTGR5, with higher selectivity for cAMP formation over β-arrestin2 recruitment. TGR5 agonist 10 exerts glucose-lowering effects in Mus musculus oral glucose tolerance tests. TGR5 agonist 10 can be used for the research of diabetes.
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DC81630 TGF-β/Smad-IN-3
TGF-β/Smad-IN-3 (Compound 4w) is an effective TGF-β/Smad inhibitor. TGF-β/Smad-IN-3 exerts anti-pulmonary fibrosis activity by simultaneously inhibiting the TGF-β/Smad and MAPK signaling pathways. TGF-β/Smad-IN-3 significantly inhibits collagen deposition induced by TGF-β1, with its IC50 value being 3.21 μM. TGF-β/Smad-IN-3 has an IC₅₀ of 46.77 nM for the autocrine motility factor (ATX). TGF-β/Smad-IN-3 significantly reduces the expression levels of α-SMA, COL1A1 and FN in TGF-β1-induced CCC-HPF-1 cells, and effectively inhibited TGF-β1-induced cell migration. TGF-β/Smad-IN-3 can be used for the study of pulmonary fibrosis.
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DC81629 TGA-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT
TGA-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT is a drug-linker conjugate for ADC. TGA-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT consists of a topoisomerase 1 inhibitor (Topi MF-6) and a cleavable linker (Maleimide-Ph(3,5-F)-PEG4-Val-Ala). TGA-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT can be used for synthesis of ADCs.
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DC81628 Tezampanel hydrate
Tezampanel (LY293558) hydrate is a potent, selective and competitive NMDA receptor antagonist. Tezampanel hydrate produces postoperative analgesia in rats. Tezampanel hydrate can be used for neuropathic pain research.
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DC81627 tert-Butyl N-methyl-N-(piperidin-4-ylmethyl)carbamate
tert-Butyl N-methyl-N-(piperidin-4-ylmethyl)carbamate is a PROTAC linker that can be used in the synthesis of PROTACs.
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DC81626 tert-Butyl N-(2-azaspiro[3.3]heptan-6-yl)carbamate hydrochloride
tert-Butyl N-(2-azaspiro[3.3]heptan-6-yl)carbamate hydrochloride is a PROTAC linker that can be used in the synthesis of PROTACs.
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DC81625 tert-Butyl 6-amino-2-azaspiro[3.3]heptane-2-carboxylate
tert-Butyl 6-amino-2-azaspiro[3.3]heptane-2-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs.
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DC81624 tert-Butyl 4-(methylamino)butylcarbamate
tert-Butyl 4-(methylamino)butylcarbamate is a PROTAC linker that can be used in the synthesis of PROTACs.
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DC81623 tert-Butyl 4-(azetidin-3-yl)piperazine-1-carboxylate
tert-Butyl 4-(azetidin-3-yl)piperazine-1-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs.
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DC81622 tert-Butyl 4-(3-hydroxypropyl)tetrahydropyridine-1(2H)-carboxylate
tert-Butyl 4-(3-hydroxypropyl)tetrahydropyridine-1(2H)-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs.
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DC81621 tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate
tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs.
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DC81620 tert-Butyl 3-cyanoazetidine-1-carboxylate
tert-Butyl 3-cyanoazetidine-1-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs.
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DC81619 tert-Butyl 3-(piperazin-1-yl)azetidine-1-carboxylate
tert-Butyl 3-(piperazin-1-yl)azetidine-1-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs.
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DC81618 tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride
tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride is a PROTAC linker that can be used in the synthesis of PROTACs.
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DC81617 tert-butyl (5-bromopentyl)carbamate
tert-butyl (5-bromopentyl)carbamate is a PROTAC linker that can be used in the synthesis of PROTACs.
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DC81616 tert-Butyl (3-(methylamino)propyl)carbamate
tert-Butyl (3-(methylamino)propyl)carbamate is a PROTAC linker that can be used in the synthesis of PROTACs.
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DC81615 tert-Butyl (2-(azetidin-3-yl)ethyl)carbamate
tert-Butyl (2-(azetidin-3-yl)ethyl)carbamate is a PROTAC linker that can be used in the synthesis of PROTACs.
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DC81614 Ternidazole
Ternidazole is a 2-methyl-5-nitroimidazole derivative and an antiprotozoal agent. Ternidazole exhibits antiprotozoal properties and is found to be effective against chronic alcoholism.
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DC81613 Terfenadine N-oxide
Terfenadine N-oxide, an N-oxide derivative of Terfenadine, is a histamine H1 receptor antagonist (IC50 = 2.73 μM) and an hERG potassium channel inhibitor (IC50 = 0.698 μM). Terfenadine N-oxide is can be used for the research of histamine-related allergic diseases and hERG channel-associated arrhythmias.
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