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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC40486 Mequindox
Mequindox is an antimicrobial agent. Mequindox acts as an inhibitor of DNA synthesis. Mequindox induces genotoxicity and carcinogenicity in mice.
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DC40485 Nor-Acetildenafil
Nor-Acetildenafil is an Acetildenafil derivative. Acetildenafil is a synthetic agent which acts as a phosphodiesterase inhibitor.
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DC40484 Homo Sildenafil
Homo Sildenafil, an analog of Sildenafil, acts as a phosphodiesterase inhibitor.
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DC40483 Malachite green isothiocyanate
Malachite green isothiocyanate is an organic perchlorate salt. It has a role as a fluorochrome. It contains a malachite green isothiocyanate cation.
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DC40482 L-Proline 4-methoxy-β-naphthylamide hydrochloride
L-Proline 4-methoxy-β-naphthylamide hydrochloride (H-Pro-4MβNA hydrochloride) can be used for Fap-activated anti-tumor compounds preparaction.
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DC40481 Z-Glu-Tyr-OH
Z-Glu-Tyr-OH can be used for synthesis of peptides on a solid support.
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DC40480 H-Gly-D-Tyr-OH
H-Gly-D-Tyr-OH is used for the the solid-phase peptide synthesis.
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DC40479 H-Asn-Arg-OH
H-Asn-Arg-OH is used for the solid-phase peptide synthesis.
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DC40478 Boc-Glu(OBzl)-OSu
Boc-Glu(OBzl)-OSu can be used for the solid-phase peptide synthesis containing glutamate benzyl ester residues.
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DC40477 Me-triacetyl-β-D-glucopyranuronate-Ph-CH2OH-Fmoc
Me-triacetyl-β-D-glucopyranuronate-Ph-CH2OH-Fmoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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DC40476 Me-triacetyl-β-D-glucopyranuronate-Ph-ald-NO2
Me-triacetyl-β-D-glucopyranuronate-Ph-ald-NO2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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DC40475 DMAC-SPDB-sulfo
DMAC-SPDB-sulfo is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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DC40474 ε-Amanitin
ε-Amanitin, a cyclic peptide isolated from a variety of mushroom species, potently binds to and inhibits the activity of RNA polymerase II.
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DC40473 (R)-8-Azido-2-(Fmoc-amino)octanoic acid
(R)-8-Azido-2-(Fmoc-amino)octanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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DC40471 EMI48
EMI48, the derivative of EMI1, displays greater potency toward mutant EGFR than EMI1. EMI48 inhibits EGFR triple mutants.
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DC40470 yGsy2p-IN-1
yGsy2p-IN-1 is a potent inhibitor for yeast glycogen synthase 2 (yGsy2p). yGsy2p-IN-1 is a competitive human glycogen synthase 1 (hGYS1) inhibitor with an IC50 of 2.75 μM and a Ki of 1.31 μM for wild-type hGYS1. yGsy2p-IN-H23 a pyrazole inhibitor, is used for glycogen storage diseases (GSDs).
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DC40469 Muscotoxin A
Muscotoxin A is an?ADC cytotoxin. Muscotoxin A is a cytotoxic lipopeptide that permeabilizes mammalian cell membranes and induces necrotic cell death.
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DC40466 HADA hydrochloride
HADA Hydrochloride is a blue fluorescent D-amino acid (FDAA). FDAAs are efficiently incorporated into the peptidoglycans (PGs) of diverse bacterial species at the sites of PG biosynthesis, allowing specific and covalent probing of bacterial growth with minimal perturbation.
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DC40465 Ned-K
Ned-K is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Ned-K is effective at dampening simulated ischaemia and reperfusion (sIR)-induced Ca2+ oscillations in cardiomyocytes.
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DC40464 MDNI-caged-L-glutamate
MDNI-caged-L-glutamate (MDNI-glu) rapidly and efficiently releases?glutamate when photolysed (350-365 nm excitation). MDNI-caged-L-glutamate is inactive at neuronal glutamate receptors (up to 200?μM) and stable at neutral pH. MDNI-caged-L-glutamate is activated by laser to evoke a rapid increase in intracellular ca2+?concentration in astrocytes.
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DC40462 Lys-CoA TFA
Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor (IC50=50-500 nM). Lys-CoA TFA displays >100-fold selectivity for p300 over PCAF (IC50=200 μM). Lys-CoA TFA inhibits p300 HAT activity-dependent transcriptional activation.
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DC40461 L-Azidonorleucine hydrochloride
L-Azidonorleucine hydrochloride, an unnatural amino acid, is A Methionine surrogate. L-Azidonorleucine hydrochloride can be used to label mammalian cell proteins and identify a diverse set of methionyl-tRNA synthetase (MetRS) mutants .
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DC40460 IHR-Cy3
IHR-Cy3 is a potent fluorescent Smo antagonist with an IC50?of 100 nM.
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DC40458 GSHtracer
GSHtracer is a ratiometric probe for measuring of GSH levels. GSHtracer exhibits Ex/Em from 520/580 nm to 430/510 nm (upon GSH binding) .
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DC40457 Fluorescein-NAD+
Fluorescein-NAD+ is an alternative to radiolabeled NAD and a substrate for ADP-ribosylation. Fluorescein-NAD+ can be used in PARP assays by fluorescence microscopy. Extinction Coefficient: 262 nm.
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DC40456 Fluorescein tyramide
Fluorescein tyramide is a green fluorescent reagent (λabs: 494 nm; λem: 517 nm). Fluorescein tyramide is widely used for tyramide signal amplification (TSA) with a low-abundance in IHC, ICC, in situ hybridization (FISH) and flow cytometry (FCM) applications.
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DC40455 Puwainaphycin F
Puwainaphycin F, a cyanobacterial cyclic lipopeptide, is a moderate cytotoxin isolated from the soil cyanobacterium Cylindrospermum alatosporum C24/89. Puwainaphycin F causes necrotic cell death to mammalian cells via cell membrane permeabilization and subsequent unusual actin relocalization.
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DC40454 Microcolin B
Microcolin B is an extremely potent unusual acylpeptide, proline-containing potent immunosuppressant. Microcolin B is isolated from blue-green alga Lyngbya majuscule.
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DC40453 Tolytoxin
Tolytoxin, a bioactive metabolite from cyanobacteria, is a potent antifungal antibiotic, exhibiting MICs of 0.25-8 nmol. Tolytoxin is a cyanobacterial macrolide that targets actin by inhibition of its polymerization. Tolytoxin has cytotoxic effects in cancer cells.
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DC40452 17-GMB-APA-GA
17-GMB-APA-GA is an ADC Cytotoxin. 17-GMB-APA-GA is a potent HSP90 inhibitor and used for latent T. gondii infection research.
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