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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC34668 Sulfacarbamide
Sulfacarbamide is an antimicrobial agent that has been investigated as a therapeutic biochemical for diabetes treatment. It may lower blood sugar.
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DC34664 Zimelidine
Zimelidine is a serotonin uptake inhibitor formerly used for depression, but was withdrawn worldwide because of the risk of Gullain-Barre syndrome associated with its use.
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DC34663 Narasin
Narasin is a novel agent that inhibits dengue virus replication in vitro through non-cytotoxic mechanisms, thus indicating its potential to be further developed as a therapeutic agent.It is used for the treatment of coccidiosis from a class of protozoa. It also triggers phospholipid scrambling of the erythrocyte cell membrane, an effect partially dependent on Ca2+ entry. It has been shown to foster apoptosis of tumor cells.
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DC34659 Pargyline
Pargyline is an irreversible selective monoamine oxidase (MAO)-B inhibitor drugwith antihypertensive properties. Pargyline has been found to bind with high affinity to the I2 imidazoline receptor (an allosteric site on the MAO enzyme).
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DC34644 Chlorphenoxamine Hydrochloride
Chlorphenoxamine HCl is an antihistaminic agent which reverses multidrug resistance in L1210 tumor cells.
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DC34622 Gentamicin X2 Sulfate
Gentamicin X2 Sulfate is a potent premature stop codon readthrough molecule and the common precursor of the gentamicin C antibiotic complex.
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DC34598 SCH-D
Vicriviroc Malate is a potent, highly selective, and orally bioavailable CCR5 antagonist.
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DC34541 Norfluoxetine hydrochloride
Norfluoxetine hydrochloride is an active metabolite of fluoxetine.
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DC34345 MP265
MP265 is an inhibitor of MreB polymerization.
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DC34312 NSC-65381
Cellocidin is a potent growth inhibitor for gammaherpesvirus-associated B-lymphomas that acts through activation of both the NF-κB and c-Myc-mediated signaling pathways.
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DC34285 GSNO
GSNO is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins. It acts by regulating diverse protein functions
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DC34267 NP-313
NP-313 is an antithrombotic agent with dual inhibition of thromboxane A2 synthesis and calcium entry.
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DC34230 5-Methylcytosine
5-Methylcytosine is a methylated cytosine. It acts as a ligand of the hDNMT1.
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DC34210 Cytidine 5'-diphosphate disodium
Cytidine 5'-diphosphate disodium is a substrate of CDP (nucleoside diphosphate) kinase (2.7.4.6). It has been shown to produce CTP in support of DNA and RNA biosynthesis and of ribonucleotide reductase to produce dCMP.
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DC34194 Sodium Oxamate
Sodium Oxamate is an LDH inhibitor. It inhibits L(+)-lactate dehydrogenase and derails the entire gluconeogenic pathway.
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DC34169 Propentofylline
Propentofylline is a phosphodiesterase inhibitor with neuroprotective effect. It was studied for the treatment of Alzheimer's disease and multi-infarct dementia, as well as its action as an adenosine reuptake inhibitor.
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DC34142 Piretanide
Piretanide is a time- and voltage-dependent blocker of CFTR Cl(-) currents. It also acts as a loop diuretic.
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DC34140 GMQ hydrochloride
GMQ hydrochloride is a potent and selective modulator of acid-sensing ion channel (ASIC). It activates ASIC3 channels under neutral pH and blocks acid-induced maximal peak current.
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DC34111 ROPA
ROPA, also known as Resiniferonol 9,13,14-ortho-phenylacetate, is a potent PKCalpha and PKCgamma activator that promotes tumor growth through PKC-activation.
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DC34094 NSC65667
SXT1596 is a novel inhibitor of the SS18-SSX/TLE1 interaction. SXT1596 decreases cell viability and reactivates EGR1 expression in synovial sarcoma.
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DC34086 2-Arachidonoylglycerol
2-Arachidonoylglycerol is an endocannabinoid, an endogenous agonist of the CB1 receptor. At a concentration of 0.3nM, 2-Arachidonoylglycerol induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a CB1 receptor-dependent mechanism.
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DC34071 Pentetrazol
Pentetrazol, also known as pentylenetetrazole, metrazol, pentetrazol (INN), pentamethylenetetrazol, Corazol, Cardiazol or PTZ, is a non-competitive GABA antagonist. It was formerly used as a drug for circulatory and respiratory stimulation.
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DC34035 Myeloperoxidase Inhibitor 1
4-POBN is a potent and irreversible inhibitor of myeloperoxidase.
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DC34033 U-0521
U-0521 is a catechol-O-methyltransferase (COMT) inhibitor. U-0521 enhances the availability and utilization of levodopa in the brain.
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DC34026 Isomaltitol
Isomaltitol, also known as Palatinit or Isomalt, is a sugar alcohol. Isomaltitol is commonly used as a sweetener in food products. There is some evidence that Isomaltitol could be used to aid mucus clearance in cystic fibrosis patients.
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DC34024 Benzetimide HCl
Benzetimide HCl, also known as EINECS 227-072-8, Spasmentral, and Dioxatrine, is a muscarinic acetylcholine receptor antagonist. Benzetimide HCl has been used to treat neuroleptic-induced parkinsonism. Benzetimide is an enantiomer of dexetimide.
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DC33805 Senecioic acid
Senecioic acid is a crystalline unsaturated fatty acid found in the pheromones of mealybug species.
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DC33792 Heptelidic acid
Heptelidic acid is an esquiterpene lactone produced by the fungus T. koningii with antibiotic activity against anaerobic bacteria such as Bacteroides. It acts as an irreversible inhibitor of GAPDH that binds to the cysteine-149 residue at the active site of the enzyme.
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DC33772 Chromotrope 2B
Chromotrope 2B is a reagent for boric acid and borates.
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DC33764 3-Benzoylpyridine
3-Benzoylpyridine is a decomposition product of the soman antidote HGG-12.
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