Eritoran tetrasodium (E5564) is an investigational drug for the treatment of severe sepsis that acts as a TLR4 antagonist..

ERGi-USU (NSC139021) is a small molecule that selectively inhibits ERG-positive cancer cell growth (VCaP cell IC50=0.169 uM), directly binds the ribosomal biogenesis regulator atypical kinase RIOK2 and induces ribosomal stress signature.

Erdosteine

ERD03 (EXOSC3-RNA disrupting compound 3) is a small molecule EXOSC3-RNA disrupting (ERD) compound that binds specifically to EXOSC3 (Kd=17 uM), induces a PCH1B-like phenotype in zebrafish.

ER-819762 is a novel potent, selective, orally active EP4 receptor antagonist with IC50 of 59 nM in cAMP-dependent reporter assay.

ER-27319 maleate is a potent, selective inhibitor of antigen or anti-IgE-mediated degranulation of rodent and human mast cells by selective inhibition of FcɛRI-mediated activation of Syk.

Equisetin is an N-methylserine-derived acyl tetramic acid produced by a number of Fusarium species with antibiotic and cytotoxic activity.

EPZ-030456 (EPZ030456) is a potent, selective SMYD3 inhibitor with biochem IC50 of 4 nM.

EPZ025654 (GSK 35336023) is a potent, selective arginine methyltransferase CARM1 inhibitor with IC50 of 3 nM.

EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7).

EPZ019997 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)).

Eprosartan is a nonpeptide angiotensin II receptor antagonist with IC50 of 9.2 and 3.9 nM in rat and human adrenal cortical membranes, respectively.

Epothilone D(Desoxyepothilone B; KOS 862) is a natural polyketide compound isolated from the myxobacterium Sorangium cellulosum.

Epothilone A is a Taxol-like microtubule-stabilizing agent that induces tubulin polymerization, leading to cell cycle arrest at the G2-M transition, cytotoxicity, and apoptosis.

Epolactaene is a neuritogenic fungal isolate that arrests the cell cycle at the G0/G1 phase and induces the outgrowth of neurites in human neuroblastoma SH-SY5Y cells.

Epibrassinolide (EBR; B1105; 24-Epibrassinolide) is a biologically active compound of the brassinosteroids, steroid-derived plant growth regulator family; was shown as a potential apoptotic inducer in various cancer cells without affecting the non-tumor c

EPI-743 (Vatiquinone,EPI-589) is an orally bioavailable para-benzoquinone for treatment of inherited mitochondrial diseases, an analogue of the antioxidant ubidecarenone.

EphB3-IN-1 is the first potent, selective inhibitor of EphB3 that exhibits inhibiting EphB3 autophosphorylation in cells with IC50 of 3 nM.

Epertinib (S-222611) is a novel potent, orally active, reversible EGFR and HER2 inhibitor with IC50 of 1.48, 7.15 and 2.49 nM for EGFR, HER2 and HER4, respectively.

EOAI3402143 (Deubiquitinase inhibitor G9, EOAI 3402143) is a novel covalent deubiquitinase Usp9x/Usp24 inhibitor with increased aqueous solubility and greater cellular Usp9x inhibitory activity than WP1130.

Enzaplatovir (BTA-585, BTA-C585) is an orally bioavailable RSV fusion protein inhibitor for the treatment of respiratory syncytial virus infections..

Enviroxime (Zinviroxime.

Entecavir is a deoxyguanosine nucleoside analogue with antiviral activity against the hepatitis B virus (HBV).

Enocitabine is an anti-tumor agent and an antineoplastic. A derivative of Cytarabine.

Enalapril maleate (Vasotec)

Enadoline (CI 977.

EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.

EML-405 (EML405) is a small-molecule inhibitor of Spindlin1 (SPIN1) with Kd of 14 uM.

Emixustat, a novel visual cycle modulator, is an inhibitor of the visual cycle isomerase with an IC50 value of 4.4 nM in vitro.

EMD534085 is a kinesin inhibitor currently in clinical development.