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Cat. No. Product Name Field of Application Chemical Structure
DC33550 YD2
YD2 is a porphyrin sensitizer. YD2 is a useful material for making solar cell. Cosensitization of YD2-o-C8 with another organic dye enhances the performance of the device, leading to a measured power conversion efficiency of 12.3% under simulated air mass 1.5 global sunlight.
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DC33549 RQ-00311651
RQ-00311651 is a novel T-type Ca2+ channel blocker, in distinct rodent models for neuropathic and visceral pain. RQ-00311651 strongly suppressed T currents when tested at holding potentials of -65 ~ -60 mV, but not -80 mV, in the Cav3.1- or Cav3.2-expressing cells. RQ-00311651 also inhibited high K-induced Ca signaling in those cells.
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DC33547 ABH free base
ABH , also known as Amino-2-Borono-6-Hexanoic Acid, is an arginase inhibitor, enhancing both male and female sexual arousal responses.
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DC33545 SSD114 HCl
SSD114 is a GABAB positive allosteric modulator. SSD114 potentiated GABA-stimulated [35S]GTPγS binding to native GABAB receptors, whereas it had no effect when used alone. SSD114, a molecule with a different chemical structure compared to known GABAB PAMs, is a novel GABAB PAM with potential usefulness in the GABAB-receptor research field.
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DC33542 D-AP7
D-AP7 is a specific NMDA antagonist and is the more active form of DL-AP7. D-AP7 enhanced motility, exhibited anxiogenic-like effect and impaired consolidation in passive avoidance.
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DC33541 Calpain Inhibitor VI
SJA6017, also known as Calpain Inhibitor VI, is a calpain inhibitor (calpain-1; IC50 = 7.5 nM) and m-calpain (calpain-2; IC50 = 78 nM). It also inhibits cathepsins B and L (IC50s = 15 and 1.6 nM, respectively). Treatment with SJA6017 reduces apoptotic cell death, preserves spinal cord tissue and improves functional outcome. Treating calpain-induced apoptosis with this agent may be a feasible therapeutic strategy for patients with spinal cord injury.
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DC33540 CU-CPT22
CU-CPT22 is the first probe for the complex between toll-like receptors TLR1 and TLR2. CU-CPT22 binds at the interface of TLR1 and TLR2 (IC50 = 0.58 μM).
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DC33539 BTT-3033
BTT-3033 is a α2β1 integrin inhibitor. BTT-3033 blocks platelet attachment under flow (90 dynes/cm(2)). The action of BTT-3033, unlike that of BTT-3034, was dependent on Tyr-285.
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DC33538 Monocrotophos
Monocrotophos is an organophosphate insecticide that blocks monoamine oxidase and acetylcholinesterase.
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DC33536 azF
4-Azido-L-phenylalanine, also known as azF, is a genetically-encoded molecular probe. azF is used to study GPCRs in their native cellular environment or under detergent solubilized conditions.
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DC33534 LPA5-IN-4
LPA5-IN-4 is the first non-lipid, small-molecule inhibitor for LPA5/GPR92, specifically inhibiting LPA-mediated platelet activation in vitro.
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DC33533 CYP3cide
PF-04981517, also known as CYP3cide, is a potent and selective time dependent inactivator of Cytochrome P450 3A4 (CYP3A4). CYP3cide is a very useful tool for understanding the relative roles of CYP3A4 versus CYP3A5 and the impact of CYP3A5 genetic polymorphism on a compound's pharmacokinetics.
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DC33532 GQ-16
GQ-16 is an effective inhibitor of Cdk5-mediated phosphorylation of PPARγ. GQ-16 improves glucose tolerance and insulin sensitivity in mouse models of obesity and diabetes without inducing weight gain or edema.
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DC33531 J1038
J1038 is a novel Inhibitor of Histone Deacetylase 8 (HDAC8).
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DC33530 HLI373
HLI373 is a water-soluble inhibitor of Hdm2. HLI373 is effective in inducing apoptosis of several tumor cells lines that are sensitive to DNA-damaging agents. HLI373 could serve as a potential lead for developing cancer therapeutics based on inhibition of the ubiquitin ligase activity of Hdm2.
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DC33529 Histomon
Nifursol is a livestock feed additive and antiobiotic used to prevent the growth of histomonas.
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DC33528 D-(+)-Neopterin
D-(+)-Neopterin is an endogenous pteridine metabolite of GTP used as an endogenous biomarker of cellular immune response and oxidative stress.
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DC33527 beta-Naphthoflavone
beta-Naphthoflavone is a AhR agonist and antioxidant. It inhibits cigarette smoked-induced DNA damage and tumor development and induces cell cycle arrest in breast cancer cells.
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DC33526 Benil
Naphazoline nitrate is α1-Adrenergic receptor agonist used to treat congestion and ocular pathologies. It also induces autophagy and necrotic cell death in erythroleukemia cells and inhibits erythroid differentiation.
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DC33525 Albalon Liquifilm
Naphazoline HCl is an α1-Adrenergic receptor agonist used to treat congestion and ocular pathologies. It also induces autophagy and necrotic cell death in erythroleukemia cells and inhibits erythroid differentiation.
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DC33524 Nadifloxacine
Nadifloxacin is a bacterial DNA gyrase inhibitor used to treat acne vulgaris. It inhibits Proponibacterium-stimulated cytokine expression and decreases production of oxidative radicals by neutrophils.
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DC33523 Myclobutanil
Myclobutanil is a 14-α demethylase inhibitor that inhibits ergosterol synthesis and fungal cell wall formation. It also weakly inhibits testosterone production.
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DC33522 Moniliformin
Moniliformin is a mycotoxin and potential dehydrogenase inhibitor found in Fusarium. It decreases collage synthesis, suppresses endocytosis, and may damage myocardial tissue.
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DC33521 Coban 45
Monensin sodium is an ionophore and inhibitor of autophagy commercially used in livestock feed. It inhibits autophagy, interfering with the fusion of the autophagosome and the lysosome.
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DC33520 BW-B 1090U
Mivacurium chloride is a non-depolarizing NMJ blocker and nAChR antagonist used as an anesthetic. It inhibits skeletal muscle contractility and prevents atrial fibrillation.
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DC33519 Andergin
Miconazole nitrate is an 14-α demethylase inhibitor and potential glucocorticoid receptor antagonist that inhibits ergosterol synthesis and fungal cell wall formation. It is used to treat fungal infections and is especially active against Candida. It also decreases expression of HIF-1α and VEGF in breast cancer and glioma cells.
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DC33518 Kavatin
Methysticin is found in Piper methysticum (kava plant). It inhibits activation of NF-χB in lung adenocarcinoma tissue, activates Nrf2 in neurons and astroglia, decreases peak amplitude of voltage-gated Na+ channels in hippocampal neurons, and suppresses growth of Fusarium, Trichoderma, and Colletotrichum.
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DC33517 7-Methyl-6-mercaptopurine
7-Methyl-6-mercaptopurine is a 6-mercaptopurine derivative and inhibitor of PRPP amidotransferase used to treat autoimmune diseases, leukemia,s and lymphomas. It inhibits IMP metabolism, preventing the synthesis of purines, DNA and RNA.
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DC33516 Methyiin
NSC-226572, also known as Alanine, 3-(methylsulfinyl)-, L-, pyrolyzate, S-methyl-L-cysteine-S-oxide; S-Methylcysteine sulfoxide, is a synthetic analog of alliin found in cruciferous vegetables including cabbage, turnip, cauliflower, and kale. NSC-226572 is converted through alliinase activity into a volatile thiosulfinate.
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DC33515 S-Methyl-L-cysteine
S-Methylcysteine is an antioxidant found in Brassicaceae family plants. It decreases oxidative stress and inhibits oil drop formation in white pre-adipose tissue.
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