A triple monoamine reuptake inhibitor that inhibits the reuptake of [3H]serotonin, [3H]norepinephrine, and [3H]dopamine in HEK 293 cells expressing the corresponding human recombinant transporters (IC50 values of 12, 23, and 96 nM, respectively).

A tripeptide representing the Fas-C terminus that specifically blocks the interaction of Fap1 with Fas.

A tricyclic pentaglycosidic, antineoplastic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA.

A topical analgesic that possesses anti-inflammatory effect for treatment of skin diseases, such as acute and chronic eczema, contact dermatitis, diaper dermatitis, miliaria and atopic dermatitis..

A Toll-like receptor modulator.

A thymidine analogue nucleoside reverse transcriptase inhibitor (NRTI) that inhibits HIV-2 isolates from treatment-naive individuals with EC50 of 30-81 nM.

A tetracycline antibiotic that acts by binding to the 30S ribosomal subunit to inhibit binding of aminoacyl tRNA which impairs protein synthesis by bacteria.

A tailored WOBE437-derived diazirine-containing photoaffinity probe that irreversibly blocks membrane transport of both endocannabinoids.

A synthetic S-acyl derivative of thiamine (vitamin B1) that possesses anti-inflammatory effects.

A synthetic peptido-mimetic compound that inhibits MyD88 dimerization in a TIR-dependent manner.

A synthetic nonpsychoactive cannabinoid acid with potent analgesic and anti-inflammatory activity in vivo, binds directly and selectively to PPARγ.

A synthetic antimicrobial compound that antibacterial activity in vitro against various Gram-positive and Gram-negative bacteria, fungi and yeast..

A synthesized pyrimidine analog that is a potent and selective anti-herpesvirus agent.

A steroid hormone with a weak androgenic effect, and an intermediate/prohormone of 11-ketotestosterone..

A staurosporine analog that promotes embryonic stem cell (ESC) differentiation by inhibiting nuclear localization of the MYC transcription factor NME2, which in turn results in down-regulation of MYC transcription.

A squalene epoxidase inhibitor that is used as an antifungal agent.

A spirocyclic fungal natural product used in treatment of fungal dermatophytes..

A specific, small molecule Bax agonist that promotes Bax-dependent but not Bak-dependent apoptosis.

A specific, non-competitive, small molecule cytochrome c oxidase (CcO or complex IV) inhibitor with IC50 of 18.93 uM (CcO from human glioma).

A specific, membrane-permeable inhibitor of Gq signaling.

A specific, irreversible inhibitor of MLK-related kinase MRK (ZAK), does not inhibit Bcr-Abl.

A specific, competitive inhibitor of 14-3-3/ligand interactions with high affinity.

A specific small molecule inhibitor of CCR5, inhibits HIV-1 entry..

A specific small molecule inhibitor of CCR5, inhibits HIV-1 entry..

A specific p38 MAPK inhibitor with IC50 of 0.6 uM.

A specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM).

A specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3.

A small-molecule, orally active inhibitor of TNF-α that reduces replication of HIV-1 (IC50=300 nM) and Mycobacterium tuberculosis in human cells.

A small-molecule, fumaric acid ester (FAE) compound that is a prodrug of methyl hydrogen fumarate (also known as monomethyl fumarate), for the treatment of relapsing-remitting multiple sclerosis and plaque psoriasis..

A small-molecule that specifically inhibits the interaction of β-catenin/LEF1 transcriptional complex in colon carcinoma cell lines.