Novel slow H2S-NO-releasing hybrid, attenuating cardiac dysfunction after heart failure

Oral active histone deacetylase inhibitor with potent antitumor activity

Novel histone deacetylase inhibitor (HDACi) with potent oral antitumor activities

Novel histone deacetylase inhibitor (HDACi) with potent oral antitumor activities

Novel next generation orally active DPP-4 inhibitor to treat Type 2 Diabetes

Cyclooxygenase-1 inhibitor

Novel inhibitor of Cyclophilin J (CyPJ) PPIase, demonstrating remarkable inhibition of tumor cell growth, comparable to CsA but much stronger than 5-fluorouracil

Novel inhibitor of Cyclophilin J (CyPJ) PPIase, demonstrating remarkable inhibition of tumor cell growth, comparable to CsA but much stronger than 5-fluorouracil

Novel multi-target inhibitor, harboring selectivity of inhibiting EGFR T790M sparing wild-type EGFR

Natural antibiotic, having diverse biological activities including broad-spectrum antibiosis against Bacteria and lower Eukarya, plant disease suppression, and enhancement of the insecticidal activity of Bacillus thuringiensis toxin against lepidopteran l

Potent, cell-permeable and irreversible caspase-1/5 inhibitor

Antagonist of D1 and D2 dopamine receptors.

Novel COX-2 inhibitor

Novel potentiator of KCNQ2 potassium channels

The first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor

Novel zinc sensor with a chloroalkane linker, reacting specifically with the engineered protein HaloTag, binding zinc ions with a threefold fluorescence enhancement

Gastroprotective agent for the treatment of peptic ulcer

Inhibitor of osteoclastogenesis and macrophage recruitment, decreasing bone turnover and stabilizing the bone matrix, exhibiting diverse anti-tumor effects in osteosarcoma

Potent, selective, and brain penetrating H2 receptor antagonist

Inducer of functional angiogenesis through increased H 2 S availability

Novel antidiabetic agent for the treatment of type 2 diabetes mellitus (DM)

Potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3)

Potassium channel opener

Selective nonpeptide, NK-2 receptor (NK-2R) antagonist

K-Channel opener (PCO) activating predominantly KATP channels in vitro to relax bladder detrusors

5-Lipoxygenase (5-LO) inhibitor

Non-steroidal pure antioestrogen

ATP-sensitive potassium channel-blocker; Eukalemic diuretic

Novel potent and highly selective inhibitor of wild-type and mutant versions of EZH2