Novel YycG inhibitor, significantly inhibited biofilm formation in static and dynamic conditions

Novel YycG inhibitor, inhibiting planktonic cells of E. faecalis, including the vancomycin- or linezolid-resistant strains

Novel inhibitor of Wnt signaling by stabilizing Axin-1, a scaffolding protein that regulates proteasome degradation of β-catenin

Novel γ-lactam pyrazolidinone, targeting penicillin-binding proteins (PBPs) and incorporating a siderophore moiety to facilitate uptake into the periplasm, being effective against multidrug-resistant gram-negative Bacilli

Selective A 2A receptor agonist

Novel Proteasome Inhibitor, Enhancing Cisplatin Cytotoxicity in Cisplatin-Resistant Human Ovarian Cancer Cells, inducing cell cycle arrest on G2 phase in MCF-7 cells via ERα and PI3K/Akt pathways

DNA-intercalating dye as sensitive amyloid probe

Novel potent orexin 1 receptor (OX1R) antagonist

Water-soluble analog of YNT-707, acting as a potent orexin 1 receptor (OX1R) antagonist

Potent and selective microbicidal agent against wild type (wt) HIV-1, NNRTI-, NRTI-, PRI-resistant mutants

Novel AMPA receptor antagonist

Potent and selective mGLu1 antagonist

Selective growth inhibitor of endothelial cells

Novel non-analogous leukotriene agonist

Novel Inducer of Apoptosis in Human Colorectal Cells via Mitochondrial Apoptosis Pathway, Inhibiting Tumor Growth

Novel, Orally Active Bioavailable Inhibitor of VEGFR2 Signaling with Potent Antiangiogenic Activity and Antitumor Efficacy

Novel salt inducible kinase (SIK) inhibitor, increasing bone formation and bone mass

Novel dual action combretastatin A-4 (CA-4) prodrug, releasing CA-4 through a disulfide bond cleavage mechanism and containing a near-infrared (NIR) fluorophore

Novel glucokinase activator, significantlt decreasing in blood glucose levels with no adverse effects on serum lipids or body weight

Novel GPR119 Agonist, improving glucose tolerance and augmenting the glucose lowering effect as well as the plasma level of active GLP-1 in normal mice in combination treatment with a dipeptidyl peptidase 4 (DPP-4) inhibitor

Novel Inhibitor of Antiapoptotic Bcl-2 Family Proteins

Tamoxifen-analog that Suppresses Glial L-Glutamate Transport Activity without Interaction with Estrogen_receptor>Estrogen Receptors

Selective Rho-associated kinase (ROCK) inhibitor

Novel, selective, soluble non-​peptidic NPY Y2 receptor antagonist with enhanced CNS exposure

Novel non-peptidic highly potent, soluble and selective NPY Y2 antagonist

Novel TRIM24/BRPF1 dual inhibitor with IC 50 values of 0.98 and 1.16 μM, respectively

Novel activator of p21 promoter in a p53-independent manner

Carbonic anhydrase inhibitor; Fungal metabolite

Novel selective β-catenin degrader

Potent modulator of P-glycoprotein-mediated multidrug resistance (MDR), inhibiting the binding of cytotoxics to P-glycoprotein