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NVS-ZP7-4

  Cat. No.:  DC30015   Featured
Chemical Structure
2349367-89-9
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More than 5000 active chemicals with high quality for research!
Field of application
NVS-ZP7-4 is a potent ZIP7 Inhibitor, which inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress. NVS-ZP7-4 altered zinc in the ER, and an analog of the compound photoaffinity labeled ZIP7 in cells, suggesting a direct interaction between the compound and ZIP7. NVS-ZP7-4 is the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2349367-89-9
Synonyms: NVS-ZP7-4; NVS-ZP7 4; NVS-ZP74; NVSZP7-4; NVSZP7 4; NVSZP74
SMILES: O=C1NC2C=CC=CC=2C2(CCN(C[C@H](CC3C=CC=CC=3)NC3SC4C(=CC=C(C=4)F)N=3)CC2)N1
Formula: C28H28FN5Os
M.Wt: 501.618227958679
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Nolin E, et al. Discovery of a ZIP7 inhibitor from a Notch pathway screen. Nat Chem Biol. 2019 Feb;15(2):179-188.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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