Lats-IN-1(TRULI )

Cas No.:	1424635-83-5
Chemical Name:	Lats-IN-1
Synonyms:	Lats-IN-1
SMILES:	O=C(C1=CNC2=NC=CC=C12)/N=C(SC=C3)/N3CC4=CC=CC=C4
Formula:	C18H14N4Os
M.Wt:	334.39
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Lats-IN-1 is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. Lats-IN-1 promotes Yap-dependent proliferation in postmitotic mammalian tissues[1].

In Vitro:

The IC50 for Lats-IN-1 increases with the ATP concentration[1]. Lats-IN-1 (10 μM; 24 hours) interferes with the ability of Lats kinases to phosphorylate Yap, with an EC50 of 510 nM[1]. Lats-IN-1 causes Yap-dependent proliferation of murine supporting cells in the inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids[1]. Lats-IN-1 fosters both the G1-S and G2-M checkpoint transitions and yields supporting cells capable of transdifferentiation[1]. Cell Proliferation Assay[1] Cell Line: MCF 10A cells Concentration: 10 μM Incubation Time: 24 hours Result: Decreased the phosphorylation of Yap at residue S127.