LC3-mHTT-IN-AN1 (Compound AN1)|CAS 486443-73-6

Cas No.:	486443-73-6
Chemical Name:	LC3-mHTT-IN-AN1 (Compound AN1)
SMILES:	BrC1C=C2/C(=C/C3C=C(O)C(O)=C(Br)C=3)/C(=O)NC2=CC=1
Formula:	C₁₅H₉Br₂NO₃
M.Wt:	411.04
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Nov;575(7781):203-209.

Description:

LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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