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8-Azaadenosine

  Cat. No.:  DC65177   Featured
Chemical Structure
10299-44-2
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More than 5000 active chemicals with high quality for research!
Field of application
8-Azaadenosine is a potent ADAR1 inhibitor and an A-to-I editing inhibitor. 8-Azaadenosine blocks RNA editing and inhibits proliferation, 3D growth, invasion, and migration in thyroid cancer cells.
Chemicals PropertiesBiological activity Related products COA MSDS Datasheet
Cas No.: 10299-44-2
Chemical Name: 3H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine,3-b-D-ribofuranosyl-
Synonyms: 3H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine,3-b-D-ribofuranosyl-;8-AZAADENOSINE;8-Aza-adenosin;8-aza-adenosine;Nsc 72961;5-d)pyrimidine,7-amino-3-beta-d-ribofuranosyl-3h-v-triazolo(;3-β-D-Ribofuranosyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine;3-triazolo(4,5-d)pyrimidin-7-amine,3-beta-d-ribofuranosyl-3h-2;3-beta-d-ribofuranosyl-3h-1,2,3-triazolo(4,5-d)pyrimidin-7-amine;3H-v-Triazolo[4,5-d]pyrimidine, 7-amino-3-.beta.-D-ribofuranosyl-;3H-1,2,3-Triazolo(4,5-D)pyrimidin-7-amine, 3-beta-D-ribofuranosyl-;3H-V-Triazolo(4,5-D)pyrimidine, 7-amino-3-beta-D-ribofuranosyl- (8ci)
SMILES: OCC1OC(N2N=NC3=C(N=CN=C23)N)C(O)C1O
Formula: C9H12N6O4
M.Wt: 268.22938
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Maria Anna Zipeto, et al. ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis. Cell Stem Cell. 2016 Aug 4;19(2):177-191. [2]. Julia Ramírez-Moya, et al. ADAR1-mediated RNA editing is a novel oncogenic process in thyroid cancer and regulates miR-200 activity. Oncogene. 2020 Apr;39(18):3738-3753.
Description: 8-Azaadenosine is a potent ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor. 8-Azaadenosine reduces A-to-I editing activity in a leukemia cell line, restores let-7 and inhibits leukemia stem cells self-renewal in vitro.
References: [1]. Maria Anna Zipeto, et al. ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis. Cell Stem Cell. 2016 Aug 4;19(2):177-191. [2]. Julia Ramírez-Moya, et al. ADAR1-mediated RNA editing is a novel oncogenic process in thyroid cancer and regulates miR-200 activity. Oncogene. 2020 Apr;39(18):3738-3753.
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