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BMS-986176

  Cat. No.:  DC58041   Featured
Chemical Structure
1815613-42-3
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More than 5000 active chemicals with high quality for research!
Field of application
AAK1-IN-1(BMS-986176) is a chemical probe for AAK1 and BIKE that potently targets the ATP-binding site (AAK1 Ki = 9.1 nM; BIKE Ki = 17 nM). Regarding kinase selectivity, only three kinases were observed to bind SGC-AAK1-1 within 30-fold of the KD of AAK1 in a KINOMEscan assay (DiscoverX) at 1 μM followed by KD determinations: RIOK1 (KD = 72 nM), RIOK3 (KD = 290 nM), and PIP5K1C (KD = 260 nM). In a live cell NanoBRET assay (Promega) SGC-AAK1-1 has potency for ectopically expressed full-length AAK1- and BIKE-Nluc fusion proteins (AAK1 IC50 = 230 nM; BIKE IC50 = 1.5 μM).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1815613-42-3
Chemical Name: BMS-986176
Synonyms: BMS-986176; BMS 986176; BMS986176
SMILES: FC(F)C1=CC(C2N=C(C(F)F)C(OC[C@@](N)(CC(C)C)C)=CC=2)=CC=N1
Formula: C19N3OF4H23
M.Wt: 385.399
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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