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ARS-1323-alkyne

  Cat. No.:  DC39116   Featured
Chemical Structure
2436544-27-1
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More than 5000 active chemicals with high quality for research!
Field of application
ARS-1323-alkyne, a switch-II pocket (S-IIP) inhibitor, is a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2436544-27-1
Synonyms: ARS-1323;ARS 1323;ARS1323
SMILES: O=C(N1CCN(C2C3C(=C(C(=C(C=3)Cl)C3C(F)=CC=CC=3O)F)N=C(NCCC(=O)N(CC#C)C)N=2)CC1)C=C
Formula: C28H27ClF2N6O3
M.Wt: 569.00
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Lou K,et al. KRASG12C inhibition produces a driver-limited state revealing collateral dependencies. Sci Signal. 2019 May 28;12(583). pii: eaaw9450.
MSDS
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MSDS_20503_DC39116_2436544-27-1
COA
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