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AT-007

  Cat. No.:  DC30011   Featured
Chemical Structure
2170729-29-8
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More than 5000 active chemicals with high quality for research!
Field of application
AT-007 is an orally active central nervous system (CNS) penetrant Aldose Reductase inhibitor for treatment of Galactosemia with an IC50 value of 100 pM. AT-007 reduces toxic galactitol levels and prevents disease complications in GALT deficiency rats.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2170729-29-8
Chemical Name: 2-(4-oxo-3-((5-(trifluoromethyl)benzo[d]thiazol-2-yl)methyl)-3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid
Synonyms: AT-007; AT 007; AT007
SMILES: O=C(CC1=NN(C(=O)C2C1=CSC=2)CC1SC2C(=CC(=CC=2)C(F)(F)F)N=1)O
Formula: C17H10F3N3O3S2
M.Wt: 425.40
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Maeve Conneighton, et al. Applied Therapeutics Announces Initiation of Phase 1/2 Study of AT-007 in Galactosemia. [2]. UNITED STATES SECURITIES AND EXCHANGE COMMISSION. APPLIED THERAPEUTICS, INC.
Description: AT-007 is an orally active central nervous system (CNS) penetrant Aldose Reductase inhibitor for treatment of Galactosemia with an IC50 value of 100 pM[1][2].
Target: IC50: 100 pM (Aldose Reductase)[2]
References: [1]. Maeve Conneighton, et al. Applied Therapeutics Announces Initiation of Phase 1/2 Study of AT-007 in Galactosemia. [2]. UNITED STATES SECURITIES AND EXCHANGE COMMISSION. APPLIED THERAPEUTICS, INC.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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