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Aslan003

  Cat. No.:  DC39627   Featured
Chemical Structure
1035688-66-4
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More than 5000 active chemicals with high quality for research!
Field of application
ASLAN003 is an orally active and potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 35 nM for human DHODH enzyme. ASLAN003 inhibits protein synthesis via activation of AP-1 transcription factors. ASLAN003 induces apoptosis and substantially prolongs survival in acute myeloid leukemia (AML) xenograft mice.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1035688-66-4
Chemical Name: Aslan003
Synonyms: Aslan003;I58WE41H6X;OMPATGZMNFWVOH-UHFFFAOYSA-N;BDBM119812;US8691852, 20;2-(3,5-difluoro-3'-methoxybiphenyl-4-ylamino)nicotinic acid;2-[(3,5-difluoro-3'-methoxy-4-biphenylyl)amino]nicotinic acid;2-((3,5-Difluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)amino)nicotinic acid;2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid;3-Pyridinecarboxylic acid, 2-((3,5-difluoro-3'-methoxy(1,1'-biphenyl)-4-yl)amin
SMILES: FC1C([H])=C(C([H])=C(C=1N([H])C1=C(C(=O)O[H])C([H])=C([H])C([H])=N1)F)C1C([H])=C([H])C([H])=C(C=1[H])OC([H])([H])[H]
Formula: C19H14F2N2O3
M.Wt: 356.322871685028
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: ASLAN003 is an orally active and potent inhibitor of DHODH (Human Dihydroorotate Dehydrogenase) which has the potential to be a first-in-class candidate in AML (Acute Myelogenous Leukemia). ASLAN003 has antitumor activity[1].
Target: DHODH[1]
References: [1]. Marco L. Lolli, et al. Human Dihydroorotate Dehydrogenase (hDHODH) as a new target on Acute Myelogenous Leukemia (AML): Targeting Myeloid Differentiation using Potent and Innovative hDHODH Inhibitors. 23rd Swedish Conference on Macromolecular Structure and Function Tällberg, 14-17 June 2019
MSDS
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