BI-0115|CAS 4929-23-1|DC Chemicals

Cas No.:	4929-23-1
Chemical Name:	BI-0115
Synonyms:	BI-0115,BI 0115,BI0115,9-Chloro-5,11-dihydro-5-propyl-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
SMILES:	ClC1C=C2C(C(=O)N(CCC)C3C(=NC=CC=3)N2)=CC=1
Formula:	C₁₅H₁₄ClN₃O
M.Wt:	287.74
Purity:	>98%
Sotrage:	-20

Description:

BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. BI-0115 binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain. The structure of LOX-1 bound to BI-0115 shows that inter-ligand interactions at the receptor interfaces are key to the formation of the receptor tetramer thereby blocking oxLDL binding.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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