CBS-1117 |CAS 959245-08-0|HA inhibitor|DC Chemicals

Cas No.:	959245-08-0
Chemical Name:	CBS1117
Synonyms:	CBS-1117;CBS 1117;CBS1117
SMILES:	CC(C)N1CCC(NC(C2=C(Cl)C=CC=C2Cl)=O)CC1
Formula:	C₁₅H₂₀Cl₂N₂O
M.Wt:	315.24
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	Structure of avian influenza hemagglutinin in complex with a small molecule entry inhibitor.

Description:	CBS1117 is a virus entry inhibitor with an IC50 of 70 nM for influenza A viruses, A/Puerto Rico/8/34 (H1N1). CBS1117 interferes with the hemagglutinin (HA)-mediated fusion process[1].
Target:	IC50: 70 nM (H1N1)[1]
In Vitro:	CBS1117 has a lower IC50 value of 70 nM and higher CC50 value of 274 μM, leading to an excellent antiviral selectivity index value (SI value of 3914) in human lung epithelial cell line (A549)[1].
References:	[1]. Hussein AFA, et al. Identification of entry inhibitors with 4-aminopiperidine scaffold targeting group 1 influenza A virus. Antiviral Res. 2020 May;177:104782.

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