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GSK-2018682

  Cat. No.:  DC10561   Featured
Chemical Structure
1034688-30-6
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More than 5000 active chemicals with high quality for research!
Field of application
GSK-2018682 is a sphingosine 1 phosphate receptor (S1PR)-1 agonist potentially for the treatment of multiple sclerosis.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1034688-30-6
Synonyms: GSK-2018682,GSK 2018682，GSK2018682
SMILES: CC(C)OC1=C(C=C(C=N1)C2=NC(=NO2)C3=C4C=CN(C4=CC=C3)CCCC(=O)O)Cl
Formula: C22H21ClN4O4
M.Wt: 440.884
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: GSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC50s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4. GSK2018682 is used in the research of multiple sclerosis.
Target: pEC50: 7.7 (S1P1 receptor), 7.2 (S1P5 receptor)[1]
In Vitro: GSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC50s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4[1].
References: [1]. Xu J, et al. Safety, pharmacokinetics, pharmacodynamics, and bioavailability of GSK2018682, a sphingosine-1-phosphate receptor modulator, in healthy volunteers. Clin Pharmacol Drug Dev. 2014 May;3(3):170-8.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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