Cat. No.:  DC22629   Featured
Chemical Structure
For research use only. We do not sell to patients.
We match the best price and quality on market.
We are official vendor of:
  • 20
  • 19
  • 18
  • 17
  • 16
  • 15
  • 14
  • 12
  • 11
  • 10
  • 9
  • 8
  • 13
  • 6
  • 5
  • 4
  • 3
  • 2
  • 1
More than 5000 active chemicals with high quality for research!
Field of application
GRL-0617 is a potent, noncovalent SARS-CoV papain-like protease (PLpro) inhibitor with IC50 of 0.6 uM, Ki of 0.49 uM.
Cas No.: 1093070-16-6
Chemical Name: (R)-5-amino-2-methyl-N-(1-(naphthalen-1-yl)ethyl)benzamide
Synonyms: GRL0617;GRL 0617
Formula: C20H20N2O
M.Wt: 304.393
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: GRL-0617 is a potent, noncovalent SARS-CoV papain-like protease (PLpro) inhibitor with IC50 of 0.6 uM, Ki of 0.49 uM; inhibits SARS-CoV viral replication in Vero E6 cells with EC50 of 14.5 uM, has no associated cytotoxicity and no inhibition for host DUBs (human deubiquitinating enzymes HAUSP, USP18, UCH-L1, UCH-L3). SARS-CoV Infection Preclinical
In Vivo:
In Vitro:
Kinase Assay:
Cell Assay:
Animal Administration:
Cat. No. Product name Field of application
DC26231 Furin Inhibitor II Inhibitor of furin (Ki values are 0.106, 0.58 and 13.2 μM for furin, PACE4 and PC1 respectively).
DC26232 DX 600(ACE2 Inhibitor) DX600 is a potent and selective peptide inhibitor of angiotensin-converting enzyme 2 (ACE2; Kis = 2.8, 200, and 1,200 nM for recombinant, human, and murine ACE2, respectively).
DC26230 Furin Inhibitor I Furin inhibitor I is a selective, irreversible, and cell-permeable competitive inhibitor of proprotein convertases, including furin/SPC1 (Ki = ~1 nM), SPC2/PC2 (Ki = 0.36 nM), SPC3/PC1/PC3 (Ki = 2.0 nM), SPC4/PACE4 (Ki = 3.6 nM), SPC6/PC5/PC6, and SPC7/LP
DC26121 FOY-251 mesylate FOY 251 is a metabolite of Camostat and a pollen protease inhibitor for prevention and control of allergy.
DC10325 Aviptadil Aviptadil (INN) is an analog of vasoactive intestinal polypeptide (VIP) for the treatment of erectile dysfunction,showed potent activity against COVID-19(SARS-COV-2).
DC7992 PX 12 PX-12(IV-2) is an irreversible inhibitor of Thioredoxin-1(Trx-1) currently in clinical development as an antitumor agent; IC50=7 uM in Hela, MTT assay, 72 h.
DC9619 Nafamostat (mesylate) Nafamostat mesylate, a synthetic serine protease inhibitor, is an anticoagulant,showed highly potent activity against COVID-19(SARS-COV-2).
DC22629 GRL-0617 GRL-0617 is a potent, noncovalent SARS-CoV papain-like protease (PLpro) inhibitor with IC50 of 0.6 uM, Ki of 0.49 uM.
DC2107 Gemcitabine HCl (Gemzar,LY188011) Gemcitabine Hydrochloride (Gemzar) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively,showed potent activity against COVID-19(SARS-COV-2) with EC50 MERS-COV(1.216), SARS-COV(4.957).
DC21979 ATF6 agonist compound A147 ATF6 agonist compound A147 is a specific, small molecule agonist of transcription factor ATF6, activates ATF6 and influences differentiation of stem cells.147 has broad antiviral activity against multiple DENV strains and serotypes and that the compound is also effective against multiple ZIKV strains.The compound has potential activity against COVID-19.