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MK-8719

  Cat. No.:  DC60003   Featured
Chemical Structure
1382799-40-7
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More than 5000 active chemicals with high quality for research!
Field of application
MK-8719 is a highly potent and selective OGA inhibitor (EC50 = 52.7 nM) which is a Potential Treatment for Tauopathies. MK-8719 showed excellent CNS penetration that has been advanced to first-in-human phase I clinical trials.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1382799-40-7
Chemical Name: MK-8719
Synonyms: MK-8719; MK 8719; MK8719;
SMILES: O[C@H]1[C@H](O)[C@@]2([H])N=C(NCC)S[C@@]2([H])O[C@@H]1C(F)F
Formula: C9H14F2N2O3S
M.Wt: 268.2788
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO Application
Description: MK-8719 is a highly potent and selective O-GlcNAcase (OGA) inhibitor (Ki=7.9 nM for hOGA) with excellent CNS penetration[1].
Target: Ki: 7.9 nM (OGA)[1]
In Vivo: MK-8719 has excellent intrinsic potency and selectivity, improved Papp, high CNS exposure, good pharmacokinetics, favorable metabolic stability, and robust pharmacodynamic response[1].
References: [1]. Selnick HG, et al. Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. J Med Chem. 2019 Sep 29.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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