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XL177A

  Cat. No.:  DC60006   Featured
Chemical Structure
2417089-74-6
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More than 5000 active chemicals with high quality for research!
Field of application
XL177A is a potent USP7 inhibitor. XL177A irreversibly inhibits USP7 with sub-nM potency and selectivity across the human proteome. Evaluation of the cellular effects of XL177A reveals that selective USP7 inhibition suppresses cancer cell growth predominantly through a p53-dependent mechanism: XL177A specifically upregulates p53 transcriptional targets transcriptome-wide, hotspot mutations in TP53 but not any other genes predict response to XL177A across a panel of ~500 cancer cell lines, and TP53 knockout rescues XL177A-mediated growth suppression of TP53 wild-type (WT) cells.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2417089-74-6
Chemical Name: N'-hydroxy-4-methylpentanimidamide
Synonyms: N-hydroxy-4-methylpentanamidine;Bio-Farma Bf034349;Bio-Farma Bf034349(WX690181);N'-hydroxy-4-methylpentanimidamide;N-Hydroxy-4-methylpentanimidamide;(E)-N'-hydroxy-4-methylpentimidamide;Pentanimidamide, N-hydroxy-4-methyl-;pentanimidamide,n-hydroxy-4-methyl-;W10718
SMILES: O([H])/N=C(/C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])\N([H])[H]
Formula: C6H14N2O
M.Wt: 130.1882
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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