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K-Ras G12C-IN-4

  Cat. No.:  DC60196   Featured
Chemical Structure
2376328-55-9
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More than 5000 active chemicals with high quality for research!
Field of application
K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRAS.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2376328-55-9
Chemical Name: K-Ras G12C-IN-4
Synonyms: K-Ras G12C-IN-4
SMILES: O=C(NC1CN(C(C=C)=O)C1)CN2C(C3CC3)=C(C(N4CC5=C(C(OC)=CC=C5)CC4)=O)C6=C2C(C)=CC(Cl)=C6
Formula: C31H33ClN4O4
M.Wt: 561.07
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRASG12C[1].
In Vitro: K-Ras G12C-IN-4 (4 hours) exhibits IC50=0.219 μM for inhibition of MAPK signaling (p-ERK) in MIA PaCa-2 cells[1]. K-Ras G12C-IN-4 (72 hours) translates to a 0.067 μM IC50 for inhibition of cellular viability in a CellTiter-Glo experiment in MIA PaCa-2 cells[1].
References: K-Ras G12C-IN-4 (4 hours) exhibits IC50=0.219 μM for inhibition of MAPK signaling (p-ERK) in MIA PaCa-2 cells[1]. K-Ras G12C-IN-4 (72 hours) translates to a 0.067 μM IC50 for inhibition of cellular viability in a CellTiter-Glo experiment in MIA PaCa-2 cells[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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