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PF-06821497

  Cat. No.:  DC60234   Featured
Chemical Structure
1844849-10-0
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More than 5000 active chemicals with high quality for research!
Field of application
PF-06821497 (compound 23a) is a potent, selective and orally active Enhancer of Zeste Homolog 2 (EZH2) inhibitor, with a Ki value <0.1 nM against mutant Y641N EZH2. Exhibits robust tumor growth inhibition.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1844849-10-0
Chemical Name: CID 118572065
Synonyms: S4L4MM20B6;5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one;GTPL10516;BDBM50246967;DB14799;compound 23a [PMID: 29211475];PF06821497;Q29209799;1(2H)-Isoquinolinone, 5,8-dichloro-2-((1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl)-3,4-dihydro-7-((R)-methoxy-3-oxetanylmethyl)-;5,8-dichloro-2-[(4-methoxy-6-m;CID 118572065
SMILES: ClC1=C2C(N(C([H])([H])C3C(N([H])C(C([H])([H])[H])=C([H])C=3OC([H])([H])[H])=O)C([H])([H])C([H])([H])C2=C(C([H])=C1[C@@]([H])(C1([H])C([H])([H])OC1([H])[H])OC([H])([H])[H])Cl)=O
Formula: C22H24Cl2N2O5
M.Wt: 467.34
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: PF-06821497 (compound 23a) is a potent, selective and orally active Enhancer of Zeste Homolog 2 (EZH2) inhibitor, with a Ki value <0.1 nM against mutant Y641N EZH2. Exhibits robust tumor growth inhibition.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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