TRPM4-IN-2 (NBA)|cas 667411-04-3|DC Chemicals

Cas No.:	667411-04-3
Chemical Name:	TRPM4-IN-2
Synonyms:	Benzoic acid, 4-chloro-2-[[2-(1-naphthalenyloxy)acetyl]amino]-;TRPM4-IN-2
SMILES:	C(O)(=O)C1=CC=C(Cl)C=C1NC(COC1=C2C(C=CC=C2)=CC=C1)=O
Formula:	C₁₉H₁₄ClNO₄
M.Wt:	355.77
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	TRPM4-IN-2 (NBA) is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC50 value of 0.16 μM. TRPM4-IN-2 can be used for researching prostate cancer and colorectal cancer[1][2].
Target:	TRPM4:0.16 μM (IC50)
In Vitro:	TRPM4-IN-2 (NBA) (50 μM; 0-500 s) blocks the endogenous TRPM4 currents in DU145[1]. Cell Proliferation Assay[1] Cell Line: DU145 Concentration: 50 μM Incubation Time: 0-500 s Result: Blocked 88 ± 9% of the endogenous TRPM4 currents at 50 μM.
References:	[1]. Borgström A, et al. Small Molecular Inhibitors Block TRPM4 Currents in Prostate Cancer Cells, with Limited Impact on Cancer Hallmark Functions. J Mol Biol. 2021 Aug 20;433(17):166665. [2]. Stokłosa P, et al. Investigation of Novel Small Molecular TRPM4 Inhibitors in Colorectal Cancer Cells. Cancers (Basel). 2021 Oct 28;13(21):5400.

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