(3S,6R)-Lateritin|cas 65454-13-9|DC Chemiclas

Cas No.:	172721-98-1
Chemical Name:	(3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1,4-perhydrooxazine-2,5-dione
Synonyms:	(3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1,4-perhydrooxazine-2,5-dione;(3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethylperhydro-1,4-oxazine-2,5-dione;Lateritin
SMILES:	C1(N(C([H])([H])[H])C(=O)C(C(C([H])([H])[H])(C([H])([H])[H])[H])([H])OC1=O)(C(c1c([H])c([H])c([H])c([H])c1[H])([H])[H])[H]
Formula:	C₁₅H₁₉NO₃
M.Wt:	261.316
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Lateritin is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), isolated from the mycelial cake of Gibberella lateritium IFO 7188[1]. Lateritin also inhibits the growth of a mini-panel of human cancer cell lines, gram-positive bacteria, and Candida albicans[2].
Target:	IC50: 6 μM (ACAT, acyl-CoA:cholesterol acyltransferase)[1]
References:	[1]. K Hasumi, et al. Lateritin, a new inhibitor of acyl-CoA:cholesterol acyltransferase produced by Gibberella lateritium IFO 7188. J Antibiot (Tokyo).1993 Dec;46(12):1782-7. [2]. Robin K Pettit, et al. Isolation of human cancer cell growth inhibitory, antimicrobial lateritin from a mixed fungal culture. Planta Med. 2010 Mar;76(5):500-1.

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