GSK3326595(pemrametostat)|cas 1616392-22-3|PRMT5 inhibitor

Cas No.:	1616392-22-3
Chemical Name:	GSK-3326595
Synonyms:	EPZ015938; EPZ 015938; EPZ-015938
SMILES:	O=C(C)N1CCC(NC2=NC=NC(C(NC[C@H](O)CN3CCC(C=CC=C4)=C4C3)=O)=C2)CC1
Formula:	C₂₄H₃₂N₆O₃
M.Wt:	452.559
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	GSK3326595 is a potent, selective, reversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC50 of 6.2 nM.
In Vitro:	GSK3326595 (EPZ015938), has entered clinical trials for the treatment of solid tumors and non-Hodgkin’s lymphoma[1].

Cat. No.	Product name	Field of application
DC8545	MI-503	MI-503 is a highly potent and orally bioavailable small molecule inhibitor of the menin-MLL interaction.
DC10560	MAK683	MAK683 is a novel PRC2/EED inhibitor.
DC10647	EPZ015938(pemrametostat)	GSK3326595(EPZ015938) is the first-in-class protein arginine methyltransferase-5 (PRMT5) inhibitor.
DC7927	EPZ011989	EPZ011989 is a potent, orally-available EZH2 Inhibitor.

EPZ015938(pemrametostat)