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HB007

  Cat. No.:  DC57071   Featured
Chemical Structure
2387821-46-5
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More than 5000 active chemicals with high quality for research!
Field of application
HB007 is a novel small-molecule degraders of the small ubiquitin-related modifier 1 (SUMO1).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2387821-46-5
Chemical Name: Urea, N -(3-chlorophenyl)-N ′-(6-cyano-2-benzothiazolyl)- (ACI)
Synonyms: HB007,HB-007,HB 007
SMILES: N#CC=1C=CC=2N=C(SC2C1)NC(=O)NC=3C=CC=C(Cl)C3
Formula: C15H9ClN4Os
M.Wt: 328.78
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors--SCIENCE TRANSLATIONAL MEDICINE •13 Oct 2021 •Vol 13, Issue 615 •DOI: 10.1126/scitranslmed.abh1486
Description: HB007 is a small ubiquitin-related modifier 1 (SUMO1) degrader. HB007 induces ubiquitination and degradation of SUMO1, resulting in reduced tumor growth in vivo. HB007 can be used for the research of brain, breast, colon, and lung cancers[1][2].
Target: SUMO1[1]
In Vivo: HB007 (compound 24) (25-50 mg/kg; i.p. for 15 d) significantly suppresses tumor growth of colon and lung cancer but had no effect on the body weights of mice[1].
In Vitro: HB007 (compound 24) (0.1-100 μM) inhibits LN229 cell growth in a concentration-dependent manner t[1]. HB007 (10-25 μM) reduces SUM01 conjugation and total protein levels of SUM01 but not SUM02/3 or UB in LN229 cells t[1].
References: [1]. Bellail AC, et, al. Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors. Sci Transl Med. 2021 Oct 13;13(615):eabh1486. [2]. BELLAIL A, et, al. Compositions and methods for treating cancer. WO2019217509A1.
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