IACS-13909|SHP2 inhibitor|CAS 2160546-07-4|DC Chemicals

Cas No.:	2160546-07-4
Chemical Name:	1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-amine
Synonyms:	IACS-13909; IACS 13909; IACS13909
SMILES:	ClC1C(Cl)=C(C2C3N=CC(=NC=3NN=2)N2CCC(N)(C)CC2)C=CC=1
Formula:	C₁₇H₁₈Cl₂N₆
M.Wt:	377.27
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

Description:

IACS-13909 is a specific and potent allosteric inhibitor of SHP2 that suppresses the signaling of RTK/MAPK pathway and overcomes multiple mechanisms underlying osimertinib resistance. IACS-13909 potently impedes the proliferation of tumors with a broad spectrum of RTKs as the oncogenic driver. Importantly, in NSCLC models with acquired resistance to osimertinib, IACS-13909 administered as a single agent or in combination with osimertinib potently reduces tumor cell proliferation in vitro and in vivo. Together, our findings provide preclinical evidence for using a SHP2 inhibitor as a therapeutic strategy in acquired EGFR inhibitor-resistant NSCLC.

MSDS

COA

LOT NO.	DOWNLOAD
2018-0101
2018-0101

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