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JWG-071

  Cat. No.:  DC39203   Featured
Chemical Structure
2250323-50-1
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More than 5000 active chemicals with high quality for research!
Field of application
JWG-071 is the first reported kinase-selective chemical probe for ERK5. JWG-071 improves ERK5 activity and BRD4 selectivity. JWG-071 will be a much-needed chemical probe for deconvoluting ERK5 and BRD4 pharmacology[1].
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2250323-50-1
Synonyms: JWG071;JWG 071
SMILES: COC1C(NC2N=C3N(C(CC)C)C4C(C(=O)N(C)C3=CN=2)=CC=CC=4)=CC=C(C(=O)N2CCC(N3CCN(C)CC3)CC2)C=1
Formula: C34H44N8O3
M.Wt: 612.76
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Wang J, et al. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinonesas Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 2018 Sep 21;13(9):2438-2448
Description: JWG-071 is the first reported kinase-selective chemical probe for ERK5. JWG-071 improves ERK5 activity and BRD4 selectivity. JWG-071 will be a much-needed chemical probe for deconvoluting ERK5 and BRD4 pharmacology[1].
Target: ERK5:88 nM (IC50)
In Vitro: JWG-071 inhibits ERK5 and LRRK2 with IC50 of 88 and 109 nM, respectively[1].
References: [1]. Wang J, et al. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinonesas Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 2018 Sep 21;13(9):2438-2448
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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