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MF-438

  Cat. No.:  DC39058   Featured
Chemical Structure
921605-87-0
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Field of application
MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an EC50 of 2.3 nM for rSCD1[1].
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 921605-87-0
Chemical Name: 2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)pyridazin-3-yl)-1,3,4-thiadiazole
Synonyms: MF-438; MF 438; MF438.
SMILES: FC(C1=CC=CC=C1OC2CCN(C3=NN=C(C4=NN=C(C)S4)C=C3)CC2)(F)F
Formula: C19H18F3N5Os
M.Wt: 421.4422
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Léger S, et al. Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438). Bioorg Med Chem Lett. 2010 Jan 15;20(2):499-502.
Description: MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an EC50 of 2.3 nM for rSCD1[1].
Target: EC50: 2.3 nM (rSCD1)[1]
In Vivo: MF-438 exhibits an ED50 between 1 and 3 mg/kg in a mouse model[1].
References: [1]. Léger S, et al. Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438). Bioorg Med Chem Lett. 2010 Jan 15;20(2):499-502.
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2018-0101
2018-0101
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