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Vonafexor(PLX007,EYP-001)

  Cat. No.:  DC31030   Featured
Chemical Structure
1192171-69-9
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More than 5000 active chemicals with high quality for research!
Field of application
Vonafexor (EYP001) is a selective FXR agonist with anti-HBV effects.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1192171-69-9
Chemical Name: PLX007(EYP-001)
Synonyms: PLX007，EYP001，EYP 001，EYP-001，PLX 007，PLX-007
SMILES: O=C(C1=CC2=C(Cl)C(N3CCN(S(=O)(C4=C(Cl)C=CC=C4Cl)=O)CC3)=CC=C2O1)O
Formula: C19H15Cl3N2O5S
M.Wt: 489.76
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Joly S, et al. The selective FXR agonist EYP001 is well tolerated in healthy subjects and has additive anti-HBV effect with nucleoside analogues in HepaRG cells. J Hepatol 66(1):S690. [2]. Fiorucci S,et al. Bile acid modulators for the treatment of nonalcoholic steatohepatitis (NASH) [published online ahead of print, 2020 Jun 19]. Expert Opin Investig Drugs. 2020;1-10.
Description: Vonafexor (EYP001) is a selective FXR agonist with anti-HBV effects[1][2].
References: [1]. Joly S, et al. The selective FXR agonist EYP001 is well tolerated in healthy subjects and has additive anti-HBV effect with nucleoside analogues in HepaRG cells. J Hepatol 66(1):S690. [2]. Fiorucci S,et al. Bile acid modulators for the treatment of nonalcoholic steatohepatitis (NASH) [published online ahead of print, 2020 Jun 19]. Expert Opin Investig Drugs. 2020;1-10.
MSDS
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