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PT2977

  Cat. No.:  DC31023   Featured
Chemical Structure
1672668-24-4
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More than 5000 active chemicals with high quality for research!
Field of application
PT2977 (MK-6482) is an orally active and selective HIF-2α inhibitor with an IC50 of 9 nM. PT2977, as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile. PT2977 is a potential treatment for clear cell renal cell carcinoma (ccRCC)[1].
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1672668-24-4
Synonyms: PT2977,MK-6482,PT2977,PT2977,MK 6482,MK6482
SMILES: N#CC1C=C(OC2C3[C@H]([C@H]([C@@H](O)C=3C(S(=O)(C)=O)=CC=2)F)F)C=C(F)C=1
Formula: C17H12F3NO4S
M.Wt: 383.34
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Xu R, et al. 3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma. J Med Chem. 2019 Aug 8;62(15):6876-6893.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
2018-0101
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