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SB-633825

  Cat. No.:  DC39018   Featured
Chemical Structure
956613-01-7
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More than 5000 active chemicals with high quality for research!
Field of application
SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC50s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 956613-01-7
Chemical Name: SB-633825
Synonyms: SB-633825;SB 633825;SB633825
SMILES: O=S(=O)(C)C1C=C(C)C(C2N(C)C(C3C=C4C(C=C(C=C4)OC)=CC=3)=C(C3C=CN=CC=3)N=2)=CC=1
Formula: C28H25N3O3S
M.Wt: 483.581
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Elkins JM, et al. Comprehensive characterization of the Published Kinase Inhibitor Set. Nat Biotechnol. 2016 Jan;34(1):95-103.
Description: SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC50s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis[1].
Target: IC50: 3.5 nM (TIE2), 66 nM (LOK) and 150 nM (BRK)[1]
In Vitro: SB-633825 inhibits TIE2 Tyrosine-protein kinase (TIE2), lymphocyte-oriented kinase (LOK; STK10) and breast tumor kinase (Brk; PTK6)[1]. SB-633825 inhibits LOK to 44% maximal activity and TIE2 to 75% maximal activity at 0.1 µM[1].
References: [1]. Elkins JM, et al. Comprehensive characterization of the Published Kinase Inhibitor Set. Nat Biotechnol. 2016 Jan;34(1):95-103.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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