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Apostatin-1 (Apt-1)

  Cat. No.:  DC39045   Featured
Chemical Structure
2559703-06-7
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Field of application
Apostatin-1 (Apt-1) is a novel TRADD inhibitor.Apostatin-1 inhibits RIPK1-dependent apoptosis (RDA) with IC50 of 1.28 μM and shows no significant off-target activity on 97 kinases in KINOME scan profiling.Inhibition of TRADD by Apostatin-1 blocks apoptosi
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2559703-06-7
Chemical Name: Apostatin-1
Synonyms: Apt-1;Apostatin-1;Apostatin-1 (Apt-1);s9705
SMILES: S(C1=NC([H])([H])C([H])([H])N1C([H])([H])[H])C([H])(C1C([H])=C([H])C([H])=C([H])C=1[H])C(N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=O
Formula: C19H27N3Os
M.Wt: 345.5022
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: Daichao Xu, Heng Zhao, Minzhi Jin, et al.Modulating TRADD to restore cellular homeostasis and inhibit apoptosis.Nature.Published: 23 September 2020
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